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Heart-specific Rpd3 downregulation enhances cardiac function and longevity.

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TypeOfResource
Text
TitleInfo
Title
Heart-specific Rpd3 downregulation enhances cardiac function and longevity.
Name (type = personal)
NamePart (type = family)
Kopp
NamePart (type = given)
Zachary A.
Role
RoleTerm (type = text); (authority = marcrt)
author
Affiliation
Cell Biology and Molecular Medicine, Rutgers University
Name (type = personal)
NamePart (type = family)
Hsieh
NamePart (type = given)
Jo-Lin
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Li
NamePart (type = given)
Andrew
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Wang
NamePart (type = given)
William
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Bhatt
NamePart (type = given)
Dhelni T.
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Angela
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Kim
NamePart (type = given)
Sae Yeon
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Fan
NamePart (type = given)
David
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Shah
NamePart (type = given)
Veevek
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Siddiqui
NamePart (type = given)
Emaad
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Ragam
NamePart (type = given)
Radhika
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Park
NamePart (type = given)
Kristen
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Ardeshna
NamePart (type = given)
Dev
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Park
NamePart (type = given)
Kunwoo
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Wu
NamePart (type = given)
Rachel
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Parikh
NamePart (type = given)
Hardik
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Parikh
NamePart (type = given)
Ayush
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Lin
NamePart (type = given)
Yuh-Ru
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Park
NamePart (type = given)
Yongkyu
Affiliation
Cell Biology and Molecular Medicine, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Cell Biology and Molecular Medicine
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (qualifier = exact); (keyDate = yes)
2015
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
16 p.
Subject (authority = local)
Topic
Rpd3
Subject (authority = local)
Topic
Cardiac function
Subject (authority = local)
Topic
Stress resistance
Subject (authority = LCSH)
Topic
Aging
Subject (authority = LCSH)
Topic
Gene expression
Subject (authority = LCSH)
Topic
Stress (Physiology)
Subject (authority = LCSH)
Topic
Cardiovascular system
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2015
AssociatedObject
Name
Aging
Type
Journal
Relationship
Has part
Detail
648-663
Identifier (type = volume and issue)
7(9)
Reference (type = url)
http://www.impactaging.com/papers/v7/n9/pdf/100806.pdf
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedObject
Type
Grant number
Name
R21AG042021
Abstract (type = abstract)
Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long‐lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregulation would improve stress resistance and/or lifespan when targeted in the heart. Contested against three different stressors (oxidation, starvation and heat), heart‐specific Rpd3 downregulation significantly enhanced stress resistance in flies. However, these higher levels of resistance were not observed when Rpd3 downregulation was targeted in other tissues or when other long‐lived flies were tested in the heart‐specific manner. Interestingly, the expressions of anti‐aging genes such as sod2, foxo and Thor, were systemically increased as a consequence of heart‐specific Rpd3 downregulation. Showing higher resistance to oxidative stress, the heart‐specific Rpd3 downregulation concurrently exhibited improved cardiac functions, demonstrating an increased heart rate, decreased heart failure and accelerated heart recovery. Conversely, Rpd3 upregulation in cardiac tissue reduced systemic resistance against heat stress with decreased heart function, also specifying phosphorylated Rpd3 levels as a significant modulator. Continual downregulation of Rpd3 throughout aging increased lifespan, implicating that Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly’s response to the environment.
RelatedItem (type = host)
TitleInfo
Title
Park, Yongkyu
Identifier (type = local)
rucore30179900001
RelatedItem (type = host)
TitleInfo
Title
Kopp, Zachary A.
Identifier (type = local)
rucore30187600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3Z89FC8
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
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RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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