Staff View
The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate

Descriptive

TypeOfResource
Text
TitleInfo
Title
The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate
Identifier (type = pmcid)
PMC4041841
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Orthopaedics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = version identification)
NOTICE: this is the author's version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, Volume 64 (July 2014) DOI: 10.1016/j.bone.2014.03.045
Note (type = peerReview)
Peer reviewed
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2014
Publisher
Elsevier
Abstract (type = Abstract)
Bisphosphonates are the most prescribed preventative treatment for osteoporosis. However, their long-term use has recently been associated with atypical fractures of cortical bone in patients who present with low-energy induced breaks of unclear pathophysiology. The effects of bisphosphonates on the mechanical properties of cortical bone have been exclusively studied under simple, monotonic, quasi-static loading. This study examined the cyclic fatigue properties of bisphosphonate-treated cortical bone at a level in which tissue damage initiates and is accumulated prior to frank fracture in low-energy situations. Physiologically relevant, dynamic, 4-point bending applied to beams (1.5 mm × 0.5 mm × 10 mm) machined from dog rib (n=12/group) demonstrated mechanical failure and micro-architectural features that were dependent on drug dose (3 groups: 0, 0.2, 1.0mg/kg/day; alendronate [ALN] for 3 years) with cortical bone tissue elastic modulus (initial cycles of loading) reduced by 21% (p<0.001) and fatigue life (number of cycles to failure) reduced in a stress-life approach by greater than 3-fold with ALN1.0 (p<0.05). While not affecting the number of osteons, ALN treatment reduced other features associated with bone remodeling, such as the size of osteons (-14%; ALN1.0: 10.5±1.8, VEH: 12.2±1.6, ×10(3) μm2; p<0.01) and the density of osteocyte lacunae (-20%; ALN1.0: 11.4±3.3, VEH: 14.3±3.6, ×10(2) #/mm2; p<0.05). Furthermore, the osteocyte lacunar density was directly proportional to initial elastic modulus when the groups were pooled (R=0.54, p<0.01). These findings suggest that the structural components normally contributing to healthy cortical bone tissue are altered by high-dose ALN treatment and contribute to reduced mechanical properties under cyclic loading conditions.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
26 p.
Subject (authority = local)
Topic
Antiresorptives
Subject (authority = local)
Topic
Atypical fracture
Subject (authority = LCSH)
Topic
Fractures
Subject (authority = LCSH)
Topic
Bone remodeling
Subject (authority = LCSH)
Topic
Osteocytes
Subject (authority = LCSH)
Topic
Osteoporosis
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2014
AssociatedObject
Name
Bone
Type
Journal
Relationship
Has part
Detail
57-64
Identifier (type = volume and issue)
64()
Reference (type = url)
http://dx.doi.org/10.1016/j.bone.2014.03.045
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
J. Christopher Fritton
AssociatedObject
Type
Grant number
Name
AR063351
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Space Biomedical Research Institute
AssociatedEntity
Role
Originator
Name
J. Christopher Fritton
AssociatedObject
Type
Grant number
Name
NASA contract NCC 9-58
Name (type = personal)
NamePart (type = family)
Bajaj
NamePart (type = given)
Devendra
Affiliation
New Jersey Medical School, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Geissler
NamePart (type = given)
Joseph R.
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Allen
NamePart (type = given)
Matthew R.
Affiliation
Indiana University School of Medicine
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Burr
NamePart (type = given)
David B.
Affiliation
Indiana University School of Medicine
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Fritton
NamePart (type = given)
J. Christopher
Affiliation
Orthopaedics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
RelatedItem (type = host)
TitleInfo
Title
Geissler, Joseph R.
Identifier (type = local)
rucore30161000001
RelatedItem (type = host)
TitleInfo
Title
Fritton, J. Christopher
Identifier (type = local)
rucore30160500001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31R6SG2
Genre (authority = ExL-Esploro)
Accepted Manuscript
Back to the top

Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Submission agreement v. 1
Detail
I am submitting manuscript on behalf of an author or grantee: I am submitting this manuscript to the NIH Manuscript Submission system on behalf of the author(s). The version deposited includes all changes resulting from the peer review process. The author has been informed that he/she will receive email confirmation of this action and that in order to complete the submission process, he/she will have to log in to the NIHMS to review and approve the submitted manuscript.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = end); (qualifier = exact); (keyDate = no)
2015-07-01
DateTime (encoding = w3cdtf); (point = start); (qualifier = exact); (keyDate = no)
2015-03-05
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after: 2015-07-01
RightsHolder (type = corporate)
Name
Elsevier Inc.
Role
Copyright holder
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
Back to the top
Version 8.3.13
Rutgers University Libraries - Copyright ©2020