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Effects of nanoparticle functionalization, shape & size on lung function & inflammation
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Botelho, Danielle Joy. Effects of nanoparticle functionalization, shape & size on lung function & inflammation. Retrieved from https://doi.org/doi:10.7282/T31J9CRR

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TitleEffects of nanoparticle functionalization, shape & size on lung function & inflammation
NameBotelho, Danielle Joy (author); Laskin, Jeffery D. (chair); Gow, Andrew J (internal member); Laumbach, Robert (internal member); SCHWANDER, STEPHAN (internal member); Zhang, Junfeng (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-10 (degree)
SubjectToxicology, Nanoparticles, Inflammation, Lungs
Extent1 online resource (viii, 105 p. : ill.)
DescriptionWith the rise of nanoparticle use in commercial products, industry, and medicine, there is a need to better understand the consequences of nanoparticle exposure. Due to their nano-scale size, the lung is a primary route of exposure. To study the effects of nanoparticle functionalization, shape and size on the lung, an organ-level toxicological approach was taken. To achieve an organ-level approach, respiratory mechanics were first evaluated using a murine model. Following ventilation, bronchoalveolar lavage was performed to obtain cells and lung lining fluid for cytokine, protein, and lipid analysis. Lastly, the lungs were harvested for assessment of tissue structure and immunohistochemistry. The collection of these endpoints allowed for a more complex approach that relates both molecular and physiological endpoints, which provides the foundation for more translational work to be done that addresses both environmental and occupational exposure risks to the public concerning nanomaterials. The data provided within this thesis validates that the primary driving factors in organ level respiratory response to nanoparticle exposure are: core composition (metal v. carbon), zeta potential, shape, and host inflammatory state. These factors affect injury and inflammation, surfactant composition and lung function. Overall, this work outlines how nanoparticle biophysics alter both lung function and inflammation.
NotePh.D.
NoteIncludes bibliographical references
Noteby Danielle Joy Botelho
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T31J9CRR
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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