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Effects of nanoparticle functionalization, shape & size on lung function & inflammation

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TitleInfo
Title
Effects of nanoparticle functionalization, shape & size on lung function & inflammation
Name (type = personal)
NamePart (type = family)
Botelho
NamePart (type = given)
Danielle Joy
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Danielle Joy Botelho
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author
Name (type = personal)
NamePart (type = family)
Laskin
NamePart (type = given)
Jeffery D.
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Jeffery D. Laskin
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Advisory Committee
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chair
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Gow
NamePart (type = given)
Andrew J
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Andrew J Gow
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Advisory Committee
Role
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internal member
Name (type = personal)
NamePart (type = family)
Laumbach
NamePart (type = given)
Robert
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Robert Laumbach
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Advisory Committee
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internal member
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SCHWANDER
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STEPHAN
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STEPHAN SCHWANDER
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Advisory Committee
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internal member
Name (type = personal)
NamePart (type = family)
Zhang
NamePart (type = given)
Junfeng
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Junfeng Zhang
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
With the rise of nanoparticle use in commercial products, industry, and medicine, there is a need to better understand the consequences of nanoparticle exposure. Due to their nano-scale size, the lung is a primary route of exposure. To study the effects of nanoparticle functionalization, shape and size on the lung, an organ-level toxicological approach was taken. To achieve an organ-level approach, respiratory mechanics were first evaluated using a murine model. Following ventilation, bronchoalveolar lavage was performed to obtain cells and lung lining fluid for cytokine, protein, and lipid analysis. Lastly, the lungs were harvested for assessment of tissue structure and immunohistochemistry. The collection of these endpoints allowed for a more complex approach that relates both molecular and physiological endpoints, which provides the foundation for more translational work to be done that addresses both environmental and occupational exposure risks to the public concerning nanomaterials. The data provided within this thesis validates that the primary driving factors in organ level respiratory response to nanoparticle exposure are: core composition (metal v. carbon), zeta potential, shape, and host inflammatory state. These factors affect injury and inflammation, surfactant composition and lung function. Overall, this work outlines how nanoparticle biophysics alter both lung function and inflammation.
Subject (authority = RUETD)
Topic
Toxicology
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Inflammation
Subject (authority = ETD-LCSH)
Topic
Lungs
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6858
PhysicalDescription
Form (authority = gmd)
electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 105 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Danielle Joy Botelho
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T31J9CRR
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Botelho
GivenName
Danielle
MiddleName
Joy
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-10-01 16:20:12
AssociatedEntity
Name
Danielle Botelho
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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windows xp
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