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Effect of staphylococcal enterotoxin A (SEA) on cell proliferation in the dentate gyrus and hippocampal-dependent learning and memory

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TitleInfo
Title
Effect of staphylococcal enterotoxin A (SEA) on cell proliferation in the dentate gyrus and hippocampal-dependent learning and memory
Name (type = personal)
NamePart (type = family)
Chang
NamePart (type = given)
Qing
NamePart (type = date)
1989-
DisplayForm
Qing Chang
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander
DisplayForm
Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Wagner
NamePart (type = given)
George
DisplayForm
George Wagner
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Shors
NamePart (type = given)
Tracey
DisplayForm
Tracey Shors
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Staphylococcal enterotoxin A (SEA) is known as a T cell superantigen, with well-characterized neurobiological and endocrine effects. We have quantified the survival of new cells, labeled with BrdU, in the dentate gyrus of the hippocampus after SEA or Saline injection into male C57BL/6 mice. A reduction of BrdU+ cells was found on Day 11 after SEA treatment, but not on Day 4. This suggests that BrdU+ cell retention was reduced by T cell activation. To determine if this decline in BrdU+ cells might predict deficits in spatial learning, a second experiment was conducted in which the effect of SEA treatment on spatial navigation learning in the Morris water maze (MWM) and the water-based Radial Arm Maze (wRAM) was investigated. Male C57BL/6J mice were given 5 ug SEA (N=7) or Saline (N=7) and then subjected to MWM hidden platform training. Two weeks after the final MWM training, mice were subjected to 8 days of water-based radial arm maze (wRAM) training. The results showed no major SEA effect on initial MWM learning. Further, wRAM learning was not affected by SEA-treated mice, but interfered with the interaction of SEA treatment and MWM pre-exposure. This may be due to a reduction in cognitive flexibility.
Subject (authority = RUETD)
Topic
Psychology
Subject (authority = ETD-LCSH)
Topic
Staphylococcal protein A
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6810
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 40 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Qing Chang
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T34B338R
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Chang
GivenName
Qing
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-09-29 02:48:25
AssociatedEntity
Name
Qing CHANG
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2017-10-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2017.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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