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Impact of Violated High-Dose Refuge Assumptions on Evolution of Bt-Resistance

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TypeOfResource
Text
TitleInfo
Title
Impact of Violated High-Dose Refuge Assumptions on Evolution of Bt-Resistance
TitleInfo (type = alternative)
Title
Evolution of Bt Resistance
Name (type = personal)
NamePart (type = family)
Campagne
NamePart (type = given)
Pascal
Affiliation
Université Paris-Sud
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Smouse
NamePart (type = given)
Peter E.
Affiliation
Ecology, Evolution and Natural Resources, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Pasquet
NamePart (type = given)
Rémy
Affiliation
International Centre for Insect Physiology & Ecology (Kenya)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Silvain
NamePart (type = given)
Jean-François
Affiliation
Université Paris-Sud
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Le Ru
NamePart (type = given)
Bruno
Affiliation
Université Paris-Sud
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Van den Berg
NamePart (type = given)
Johnnie
Affiliation
North-West University (South Africa)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Ecology, Evolution and Natural Resources
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Environmental and Biological Sciences (SEBS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
Publisher
Wiley
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2016
Abstract (type = Abstract)
Transgenic crops expressing Bacillus thuringiensis (Bt) toxins have been widely and successfully deployed for the control of target pests, while allowing a substantial reduction of insecticide use. The evolution of resistance (a heritable decrease in susceptibility to Bt toxins) can pose a threat to sustained control of target pests, but a high-dose refuge (HDR) management strategy has been key to delaying countervailing evolution of Bt resistance. The HDR strategy relies on the mating frequency between susceptible and resistant individuals, so either partial dominance of resistant alleles or non-random mating in the pest population itself could elevate the pace of resistance evolution. Using classic Wright-Fisher genetic models, we investigated the impact of deviations from standard refuge model assumptions on resistance evolution in the pest populations. We show that when Bt selection is strong, even deviations from random mating and/or strictly recessive resistance that are below the threshold of detection can yield dramatic increases in the pace of resistance evolution. Resistance evolution is hastened whenever the order of magnitude of model violations exceeds the initial frequency of resistant alleles. We also show that existence of a fitness cost for resistant individuals on the refuge crop cannot easily overcome the effect of violated HDR assumptions. We propose a parametrically explicit framework that enables both comparison of various field situations and model inference. Using this model, we propose novel empiric estimators of the pace of resistance evolution (and time to loss of control), whose simple calculation relies on the observed change in resistance allele frequency.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
40 p.
Subject (authority = LCSH)
Topic
Insecticide resistance
Subject (authority = local)
Topic
Refuge strategy
Subject (authority = local)
Topic
High-dose
Subject (authority = local)
Topic
Partial dominance
Subject (authority = local)
Topic
Non-random mating
Subject (authority = local)
Topic
Fitness cost
Subject (authority = local)
Topic
Incomplete resistance
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
Evolutionary Applications
Type
Journal
Relationship
Has part
Reference (type = url)
http://dx.doi.org/10.1111/eva.12355
Identifier (type = volume and issue)
9(4)
Detail
596-607
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
U.S. Department of Agriculture
AssociatedEntity
Role
Originator
Name
Peter Smouse
AssociatedObject
Type
Grant number
Name
17160
RelatedItem (type = host)
TitleInfo
Title
Smouse, Peter E.
Identifier (type = local)
rucore30184700001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30G3N4Q
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004); (TYPE = [FS] statement #1)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsHolder (type = personal)
Name
FamilyName
Campagnea
GivenName
Pascal
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Smouse
GivenName
Peter
MiddleName
E.
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Pasqueta
GivenName
Rémy
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Silvaina
GivenName
Jean-François
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Le Rua
GivenName
Bruno
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Van den Berg
GivenName
Johnnie
Role
Copyright holder
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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