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Arterial hemodynamics and its interaction with the left ventricle in heart failure

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TitleInfo
Title
Arterial hemodynamics and its interaction with the left ventricle in heart failure
Name (type = personal)
NamePart (type = family)
Hegyi
NamePart (type = given)
Gina N.
NamePart (type = date)
1991-
DisplayForm
Gina N. Hegyi
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Li
NamePart (type = given)
John K-J.
DisplayForm
John K-J. Li
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Monitoring heart-arterial system (LV-AS) interactions of cardiovascular patients is important in achieving successful diagnosis and treatment. This is particularly true in the cases of hypertension and heart failure. However, there has been limited quantitative hemodynamic analysis aimed at improving the outcome for the 70-million hypertensive patients and millions of heart failure patients. This thesis develops a model-based strategy to provide a comprehensive evaluation of the state of the vascular system and its coupling to the heart, and ultimately aims to distinguish patient groups of heart failure with preserved or reduced ejection fraction (HFpEF and HFrEF). The first aspect of this study is analysis of arterial hemodynamics from animal experimental data collected during normotensive, vasodilation, and induced hypertension conditions. Total arterial compliance (C), peripheral resistance (Rs), and aortic characteristic impedance (Z0) based on the 3-element Windkessel model were obtained, together with frequency-domain impedance, wave reflection information, and parameters for assessing global cardiac function. Subsequently, clinical human data were collected and analyzed, focusing on the LV-AS interactions. We identified critical parameters in LV-AS interaction, i.e. effective arterial system elastance, Ea, LV systolic elastance, Emax, LV-AS coupling index, k (=Ea/Emax), and C. Results characterized hypertension by a significantly reduced C and increased Rs, confirmed by increased vascular impedance and wave reflections. Unloading the heart reversed these observations via vasodilator treatment. For human studies, we found C to be more effective than Ea in distinguishing groups of HFpEF and HFrEF patients. It was found that HFpEF patients tended to have a relatively independent coupling index, k, with respect to arterial parameter changes. The findings in this work can be incorporated into larger scale clinical studies that implement the use of pulse waveform analysis and the identified critical LV-AS interaction parameters to improve patient treatment and outcome.
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = ETD-LCSH)
Topic
Heart failure
Subject (authority = ETD-LCSH)
Topic
Hemodynamics
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6818
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (v, 106 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Gina N. Hegyi
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3QN68RM
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Hegyi
GivenName
Gina
MiddleName
N.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-09-29 14:26:20
AssociatedEntity
Name
Gina Hegyi
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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ETD
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windows xp
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