RUcore: Rutgers University Community Repository
Representation of the body in the lateral striatum of the freely moving rat
Descriptive
TitleInfo
Title
Representation of the body in the lateral striatum of the freely moving rat
SubTitle
responsiveness of fast spiking interneurons to stimulation of individual body parts
Name
(type = personal)
NamePart
(type = family)
Kulik
NamePart
(type = given)
Julianna
DisplayForm
Julianna Kulik
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
West
NamePart
(type = given)
Mark
DisplayForm
Mark West
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Kusnecov
NamePart
(type = given)
Alexander
DisplayForm
Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
co-chair
Name
(type = personal)
NamePart
(type = family)
Koos
NamePart
(type = given)
Tibor
DisplayForm
Tibor Koos
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(encoding = w3cdtf);
(qualifier = exact)
2015
DateOther
(qualifier = exact);
(type = degree)
2015-10
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Numerous studies have shown that certain types of striatal interneurons might play a crucial role in selection and regulation of striatal output. Among these, striatal Fast-Spiking Interneurons (FSIs) are parvalbumin positive, GABAergic interneurons that constitute less than 1% of the total striatal population. FSIs display a strong medial<lateral distribution gradient across the striatum, which suggests that they are important for regulation of motor functions subsumed within the lateral striatum. It is becoming increasingly evident that these sparsely distributed neurons exert a strong inhibitory effect on Medium Spiny projection Neurons (MSNs), the principal neurons of the striatum. MSNs in lateral striatum receive direct synaptic input from regions of cortex representing discrete body parts. Individual MSNs show phasic increases in activity during touch or movement of specific body parts. In the present study, we sought to determine whether lateral striatal FSIs identified by their distinct electrophysiological properties, i.e., short-duration spike and fast firing rate, display body part sensitivity similar to that exhibited by MSNs. Using a video recorded sensorimotor exam, each individual body part was stimulated and responses of single neurons were observed and quantified. Approximately half of the identified FSIs displayed patterns of activity related selectively to stimulation of discrete body parts. Those patterns of activity were often similar to those exhibited by typical MSNs in the lateral striatum. Some FSIs displayed patterns of activity different from those described in for MSNs, such as a dramatic decrease in firing during movement of the related body part. Together these results serve as evidence that striatal FSIs process information related to discrete body parts and participate in control of motor output by the striatum.
Subject
(authority = RUETD)
Topic
Psychology
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6787
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (v, 28 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Interneurons
Note
(type = statement of responsibility)
by Julianna Kulik
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3F191P8
Genre
(authority = ExL-Esploro)
ETD graduate
Back to the top
Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Kulik
GivenName
Julianna
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-09-25 12:55:38
AssociatedEntity
Name
Julianna Kulik
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top
Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
Back to the top
Statistical Profile