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Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA

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TypeOfResource
Text
TitleInfo
Title
Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA
TitleInfo (type = alternative)
Title
OFQ inhibits dendrite growth via RhoA
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-5694-4946)
NamePart (type = family)
Alder
NamePart (type = given)
Janet
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Kallman
NamePart (type = given)
Seth
Affiliation
Robert Wood Johnson Medical School (RWJMS)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Palmieri
NamePart (type = given)
Alicia
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Khadim
NamePart (type = given)
Farah
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Ayer
NamePart (type = given)
Jennifer J.
Affiliation
Waksman Institute of Microbiology
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Kumar
NamePart (type = given)
Sujata
Affiliation
Robert Wood Johnson Medical School (RWJMS)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Tsung
NamePart (type = given)
Katherine
Affiliation
Robert Wood Johnson Medical School (RWJMS)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Grinberg
NamePart (type = given)
Ilya
Affiliation
Robert Wood Johnson Medical School (RWJMS)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Thakker-Varia
NamePart (type = given)
Smita
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Neuroscience and Cell Biology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Robert Wood Johnson Medical School (RWJMS)
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Waksman Institute of Microbiology
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2013
Abstract (type = Abstract)
Brain-derived neurotrophic factor (BDNF) plays a facilitatory role in neuronal development and promotion of differentiation. Mechanisms that oppose BDNF's stimulatory effects create balance and regulate dendritic growth. However, these mechanisms have not been studied. We have focused our studies on the BDNFinduced neuropeptide OrphaninFQ/Nociceptin (OFQ); while BDNF is known to enhance synaptic activity, OFQ has opposite effects on activity, learning and memory. We have now examined whether OFQ provides a balance to the stimulatory effects of BDNF on neuronal differentiation in the hippocampus. Golgi staining in OFQ knockout (KO) mice revealed an increase in primary dendrite length as well as spine density, suggesting that endogenous OFQ inhibits dendritic morphology. We have also used cultured hippocampal neurons to demonstrate that exogenous OFQ has an inhibitory effect on dendritic growth and that the neuropeptide alters the response to BDNF when re-administered. To determine if BDNF and OFQ act in a feedback loop, we inhibited the actions of the BDNF and OFQ receptors, TrkB and NOP using ANA-12 and NOP KO mice respectively but our data suggests that the two factors do not act in a negative feedback loop. We found that the inhibition of dendritic morphology induced by OFQ is via enhanced RhoA activity. Finally, we have evidence that RhoA activation is required for the inhibitory effects of OFQ on dendritic morphology. Our results reveal basic mechanisms by which neurons not only regulate the formation of proper dendritic growth during development but also control plasticity in the mature nervous system.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
60 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2013
AssociatedObject
Name
Developmental Neurobiology
Type
Journal
Relationship
Has part
Detail
769-784
Identifier (type = volume and issue)
73(10)
Reference (type = url)
https://dx.doi.org/10.1002/dneu.22101
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
Subject (authority = local)
Topic
Brain-derived neurotrophic factor
Subject (authority = local)
Topic
Orphanin FQ/nociceptin
Subject (authority = LCSH)
Topic
Neuropeptides
Subject (authority = LCSH)
Topic
Dendrites
Subject (authority = local)
Topic
RhoA
Note (type = version identification)
This is the peer reviewed version of the following article: Alder, J., Kallman, S., Palmieri, A., Khadim, F., Ayer, J. J., Kumar, S., Tsung, K., Grinberg, I. and Thakker-Varia, S. (2013), Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. Devel Neurobio, 73: 769–784, which has been published in final form at https://dx.doi.org/10.1002/dneu.22101. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Note (type = peerReview)
Peer reviewed
RelatedItem (type = host)
TitleInfo
Title
Alder, Janet
Identifier (type = local)
rucore30160300001
RelatedItem (type = host)
TitleInfo
Title
Thakker-Varia, Smita
Identifier (type = local)
rucore30188900001
RelatedItem (type = host)
TitleInfo
Title
Ayer, Jennifer J.
Identifier (type = local)
rucore30194300001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T34F1SQ4
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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Copyright protected
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Open
Reason
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Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
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RightsEvent
Type
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Detail
This is the peer reviewed version of the following article: Alder, J., Kallman, S., Palmieri, A., Khadim, F., Ayer, J. J., Kumar, S., Tsung, K., Grinberg, I. and Thakker-Varia, S. (2013), Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. Devel Neurobio, 73: 769–784, which has been published in final form at https://dx.doi.org/10.1002/dneu.22101. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
RightsHolder (type = corporate)
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