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The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus

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TypeOfResource
Text
TitleInfo
Title
The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Neuroscience and Cell Biology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Robert Wood Johnson Medical School (RWJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2007
Abstract (type = Abstract)
Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by antidepressant treatments and BDNF produces antidepressant-like effects in behavioral models of depression. In our previous work, we identified genes induced by BDNF and defined their specific roles in hippocampal neuronal development and plasticity. To identify genes downstream of BDNF that may play roles in psychiatric disorders, we have examined a subset of BDNF-induced genes also regulated by serotonin (5-HT), which includes the neuropeptide VGF (non-acronymic). To explore the function of VGF in depression, we first investigated the expression of the neuropeptide in animal models of depression. VGF was downregulated in the hippocampus following both the learned helplessness (LH) and forced swim test (FST) paradigms. Conversely, VGF infusion in the hippocampus of mice subjected to FST reduced the time spent immobile for up to 6 days, thus demonstrating a novel role for VGF as an antidepressant-like agent. Recent evidence indicates that chronic treatment of rodents with antidepressants increases neurogenesis in the adult dentate gyrus and that neurogenesis is required for the behavioral effects of antidepressants. Our studies using 3H-thymidine and bromodeoxyuridine (BrdU) as markers of DNA synthesis indicate that chronic VGF treatment enhances proliferation of hippocampal progenitor cells both in vitro and in vivo with survival up to 21d. By double immunocytochemical analysis of hippocampal neurons, we demonstrate that VGF increases the number of dividing cells that express neuronal markers in vitro. Thus VGF may act downstream of BDNF and exert its effects as an antidepressant-like agent by enhancing neurogenesis in the hippocampus.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
12 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2007
AssociatedObject
Name
The Journal of Neuroscience
Type
Journal
Relationship
Has part
Detail
12156-12167
Identifier (type = volume and issue)
27(45)
Reference (type = url)
https://dx.doi.org/10.1523/JNEUROSCI.1898-07.2007
Subject (authority = LCSH)
Topic
Antidepressants
Subject (authority = LCSH)
Topic
Brain-derived neurotrophic factor
Subject (authority = LCSH)
Topic
Neuropeptides
Subject (authority = LCSH)
Topic
Serotonin
Subject (authority = LCSH)
Topic
Cell proliferation
Subject (authority = local)
Topic
Transcription
Name (type = personal)
NamePart (type = family)
Thakker-Varia
NamePart (type = given)
Smita
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Krol
NamePart (type = given)
Jennifer Jernstedt
Affiliation
Waksman Institute of Microbiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Nettleton
NamePart (type = given)
Jacob
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Bilimoria
NamePart (type = given)
Parizad M.
Affiliation
Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Bangasser
NamePart (type = given)
Debra A.
Affiliation
Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Shors
NamePart (type = given)
Tracey J.
Affiliation
Psychology (New Brunswick)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Black
NamePart (type = given)
Ira B.
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-5694-4946)
NamePart (type = family)
Alder
NamePart (type = given)
Janet
Affiliation
Neuroscience and Cell Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Psychology (New Brunswick)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Rutgers School of Public Health (SPH)
RelatedItem (type = host)
TitleInfo
Title
Alder, Janet
Identifier (type = local)
rucore30160300001
RelatedItem (type = host)
TitleInfo
Title
Ayer, Jennifer J.
Identifier (type = local)
rucore30194300001
RelatedItem (type = host)
TitleInfo
Title
Nettleton, Jacob
Identifier (type = local)
rucore30209600001
RelatedItem (type = host)
TitleInfo
Title
Shors, Tracey J.
Identifier (type = local)
rucore30209700001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3MG7RH0
Genre (authority = ExL-Esploro)
Journal Article
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
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Availability
Status
Open
Reason
Permission or license
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Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.3
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2007-10-30T17:13:17
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-07-19T16:40:45
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