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Intrinsic and synaptic membrane responses of murine spiral ganglion neurons
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Liu, Wenke. Intrinsic and synaptic membrane responses of murine spiral ganglion neurons. Retrieved from https://doi.org/doi:10.7282/T3Q81G2F

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TitleIntrinsic and synaptic membrane responses of murine spiral ganglion neurons
NameLiu, Wenke (author); Davis, Robin L (chair); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-10 (degree)
SubjectNeuroscience, Neurons, Synapses
Extent1 online resource (xi, 104 p. : ill.)
DescriptionAs the first neuronal element in the auditory pathway, spiral ganglion neurons are responsible for the initial signal encoding of complex sound information. Experiments presented in this dissertation explore the physiological basis of coding capacity in the murine postnatal spiral ganglion using electrophysiological and immunocytochemical techniques. Three separate and complete studies are presented. First, heterogeneity within each tonotopic region of the ganglion was characterized by the distribution patterns of calretinin and calbindin, two widely used markers for neuronal subpopulations (Liu and Davis, 2014). Second, the developmental establishment of diverse firing patterns in the spiral ganglion was investigated in embryonic cochlear epithelial cells in which neurogenic transcription factors were overexpressed (Nishimura et al., 2014). Finally, recordings made from acute cochlear whole-mounts preparations were made to assess the diverse intrinsic firing features in comparison to invading action potentials and passively-propagated synaptic potentials (Liu and Davis, in preparation). Results from these studies suggest that the physiological heterogeneity within the spiral ganglion may contribute to a population code essential for conveying the rich content of auditory information.
NotePh.D.
NoteIncludes bibliographical references
Noteby Wenke Liu
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3Q81G2F
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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