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Investigating the applicability of the compensatory reserve index for forecasting intracranial pressure events
Descriptive
TitleInfo
Title
Investigating the applicability of the compensatory reserve index for forecasting intracranial pressure events
Name
(type = personal)
NamePart
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Pineda
NamePart
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Bianca
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Bianca Pineda
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Craelius
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(type = given)
Willliam
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Willliam Craelius
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Advisory Committee
Role
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chair
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(type = personal)
NamePart
(type = family)
Hacihaliloglu
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Ilker
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Ilker Hacihaliloglu
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Advisory Committee
Role
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internal member
Name
(type = personal)
NamePart
(type = family)
Kaplan
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(type = given)
Hilton
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Hilton Kaplan
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Khan
NamePart
(type = given)
John
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John Khan
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
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2015
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(type = degree)
2015-10
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2015
Place
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xx
Language
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(type = code)
eng
Abstract
(type = abstract)
There are about 1.7 million cases of traumatic brain injury in the U.S. annually. After injury, the body’s compensatory mechanisms cause fluid to accumulate in the cranium. This gives rise to elevated intracranial pressure (ICP) which then causes ischemia. To compensate for this, vessels dilate causing more fluid to build and the cycle to repeat. If left unchecked, this cycle compromises cerebral autoregulation such that the body cannot maintain stable ICP in response to changes in volume. This leads to intracranial hypertension and secondary injuries such as hemorrhaging, etc. In order to prevent secondary injury, the standard of care for patients with moderate to severe head injuries is to monitor their ICP in surgical intensive care units. However, treatments are only implemented after ICP has reached a critical value and noticeable damage has occurred. The goal of this project is to develop a method to forecast the occurrence of these critical events in ICP so that treatments can be applied preemptively. Working towards this goal, a numerical descriptor of cerebral autoregulation called the compensatory reserve index (RAP) was analyzed for its potential ability to forecast rises in ICP. Retrospective data was analyzed from two patients with TBI who were monitored for 38 and 340 hours, respectively. Hours were separated into either ‘stable’ or ‘unstable’ periods of ICP according to established rules and RAP calculated for each hour. Results showed that, 1) the cumulative distribution of RAP calculated in ‘stable’ ICP periods differs significantly from that in ‘unstable’ periods (p < 0.001), 2) in several instances of ICP elevation, RAP exceeded the set threshold in both patients with latency values normally between 1-3 minutes. Thus, the results support the hypothesis that RAP is significantly associated with hemodynamic instability and its potential as a predictor of the same.
Subject
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Topic
Biomedical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_6843
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xi, 45 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Brain--Wounds and injuries
Subject
(authority = ETD-LCSH)
Topic
Intracranial pressure
Note
(type = statement of responsibility)
by Bianca Pineda
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3GH9KX5
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Pineda
GivenName
Bianca
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2015-09-30 19:49:34
AssociatedEntity
Name
Bianca Pineda
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2015-10-31
DateTime
(encoding = w3cdtf);
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(point = end)
2016-05-01
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 1st, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
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windows xp
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