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Intermittent Fasting Promotes Fat Loss with Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice

Descriptive

TypeOfResource
Text
TitleInfo
Title
Intermittent Fasting Promotes Fat Loss with Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice
Name (type = personal)
NamePart (type = family)
Gotthardt
NamePart (type = given)
Juliet D.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Verpeut
NamePart (type = given)
Jessica L.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yeomans
NamePart (type = given)
Bryn L.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yang
NamePart (type = given)
Jennifer A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Yasrebi
NamePart (type = given)
Ali
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0001-5426-2266)
NamePart (type = family)
Roepke
NamePart (type = given)
Troy A.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Bello
NamePart (type = given)
Nicholas T.
Affiliation
Animal Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Animal Sciences
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Environmental and Biological Sciences (SEBS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
Publisher
Endocrine Society
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2016
Abstract (type = Abstract)
Clinical studies indicate alternate day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet (HFD; 45% fat) ad libitum for 8 weeks to promote an obese phenotype. Mice were divided into 4 groups and either maintained on ad libitum HFD (HFD), received alternate day access to HFD (IMF- HFD), switched to ad libitum low fat diet (LFD; 10% fat), or received IMF of LFD (IMF- LFD). After 4 weeks, IMF-HFD (~13%) and IMF-LFD (~18%) had significantly lower body weights than HFD. Body fat was also lower (~40-52%) in all diet interventions. Lean mass was increased in the IMF-LFD (~12-13%) compared with HFD and IMF-HFD groups. Oral glucose tolerance AUC was lower in the IMF-HFD (~50%), whereas insulin tolerance AUC was reduced in all diet interventions (~22-42%). HPLC measurements of hypothalamic tissue homogenates indicated higher (~55-60%) norepinephrine (NE) content in the anterior regions of the medial hypothalamus of IMF compared with ad libitum fed groups, whereas NE content was higher (~19-32%) in posterior regions in the IMF-LFD group only. Relative gene expression of Npy in the arcuate nucleus was increased (~65-75%) in IMF groups. Our novel findings indicate that intermittent fasting produces alterations in hypothalamic NE and NPY, suggesting an involvement in the counter regulatory processes of short-term weight loss are associated with an IMF dietary strategy.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
31 p.
Subject (authority = local)
Topic
Dieting
Subject (authority = LCSH)
Topic
Reducing diets
Subject (authority = LCSH)
Topic
Intermittent fasting
Subject (authority = LCSH)
Topic
Appetite
Subject (authority = LCSH)
Topic
Adrenaline--Receptors
Subject (authority = local)
Topic
Feeding
Subject (authority = local)
Topic
Meal-feeding
Subject (authority = local)
Topic
Short-term weight loss
Subject (authority = local)
Topic
Therapeutic strategies
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
Endocrinology
Type
Journal
Relationship
Has part
Identifier (type = volume and issue)
157(2)
Reference (type = url)
http://dx.doi.org/10.1210/en.2015-1622
Detail
679-691
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institute of Food and Agriculture
AssociatedEntity
Role
Originator
Name
Troy A. Roepke
AssociatedObject
Type
Grant number
Name
R00DK083457
AssociatedObject
Type
Grant number
Name
R00DK083457-S1
AssociatedObject
Type
Grant abstract
Name
P30ED005022
AssociatedObject
Type
Grant number
Name
NJ06107
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institute of Food and Agriculture
AssociatedEntity
Role
Originator
Name
Nicholas T. Bello
AssociatedObject
Type
Grant number
Name
NJ06156
RelatedItem (type = host)
TitleInfo
Title
Roepke, Troy A.
Identifier (type = local)
rucore30176800001
RelatedItem (type = host)
TitleInfo
Title
Gotthardt, Juliet D.
Identifier (type = local)
rucore30190400001
RelatedItem (type = host)
TitleInfo
Title
Yeomans, Bryn L.
Identifier (type = local)
rucore30190500001
RelatedItem (type = host)
TitleInfo
Title
Yang, Jennifer A.
Identifier (type = local)
rucore30190600001
RelatedItem (type = host)
TitleInfo
Title
Yasrebi, Ali
Identifier (type = local)
rucore30190700001
RelatedItem (type = host)
TitleInfo
Title
Bello, Nicholas T.
Identifier (type = local)
rucore30190300001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3FJ2JRW
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
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RightsHolder (type = corporate)
Name
Endocrine Society
Role
Copyright holder
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RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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