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Design, synthesis, and formulation of bioactive-based polymers

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TitleInfo
Title
Design, synthesis, and formulation of bioactive-based polymers
SubTitle
controlled delivery via biodegradation
Name (type = personal)
NamePart (type = family)
Stebbins
NamePart (type = given)
Nicholas David
DisplayForm
Nicholas David Stebbins
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Uhrich
NamePart (type = given)
Kathryn E
DisplayForm
Kathryn E Uhrich
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Romsted
NamePart (type = given)
Laurence
DisplayForm
Laurence Romsted
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Warmuth
NamePart (type = given)
Ralf
DisplayForm
Ralf Warmuth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Skelly
NamePart (type = given)
Susan
DisplayForm
Susan Skelly
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2015
DateOther (qualifier = exact); (type = degree)
2015-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2015
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Biodegradable, bioactive-based polymers have been successfully employed as sustained bioactive delivery systems. This dissertation describes bioactives that have been chemically incorporated into novel, biodegradable polymers via covalent bonds for controlled, sustained, and tunable release properties. Bioactives are released from polymers via hydrolytic degradation. The polymers described herein utilize alternative synthetic methods and a wide array of bioactives, including antibiotics, antioxidants, antimicrobials, and anti-inflammatory drugs. One goal is to focus on naturally-occurring bioactives that are generally regarded as safe (GRAS) by the FDA. First, poly(anhydride-amides) comprised of ampicillin were synthesized and formulated as coatings. Polymer adhesion onto medical-grade stainless steel surfaces was assessed and in vitro release characterized. Cytocompatibility and antibacterial activity elucidated polymer safety and efficacy for potential in vivo use. These localized delivery systems could mediate the issues caused by implant surgery. Second, poly(anhydride-esters) comprised solely of naturally-occurring phenols and EDTA were synthesized and physicochemical properties determined. Bioactive release was ascertained, in addition to antioxidant activity and activity against Gram-positive and Gram-negative bacteria. These polymers can act as potential preservatives, increasing cosmetic and food product shelf life through antioxidant and antimicrobial pathways. Third, through environmentally sustainable (i.e, green) methods, polyesters with pendant anti-inflammatory groups and a sugar-based backbone were prepared with minimal solvent use, enzymatic catalysis, and biorenewable reactants and reagents. Three comonomers of varying hydrophobicity were tested to elucidate changes in polymer thermal properties and bioactive release rate. Fourth, poly(anhydride-esters) with a mannitol backbone and multiple bioactive groups per repeat unit were developed as the first linear, biodegradable polymers with high bioactive loading (~70%) using a polyol. In vitro ibuprofen release was quantified and an anti-inflammatory assay determined that bioactive retained activity upon polymer degradation. Alteration of polyol, bioactive class, and other facets leads to highly tunable polymer properties. Last, to combat bacterial spoilage and oxidation, poly(anhydride-esters) containing natural antimicrobials were designed for food applications. Bioactive released from polymer exhibited radical scavenging ability and antibacterial activity. Furthermore, polymers were blended with current food packaging materials (e.g., polyethylene) and molded into films for active food packaging that contains a higher percentage of biodegradable content.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (authority = ETD-LCSH)
Topic
Biopolymers
Subject (authority = ETD-LCSH)
Topic
Polymers
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6558
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxiv, 164 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Nicholas David Stebbins
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3NZ89NX
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Stebbins
GivenName
Nicholas
MiddleName
David
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-05-27 14:28:08
AssociatedEntity
Name
Nicholas Stebbins
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2016-10-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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