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Profile analysis and In vitro absorption study of citrus peel polymethoxyflavones
Descriptive
TitleInfo
Title
Profile analysis and In vitro absorption study of citrus peel polymethoxyflavones
Name
(type = personal)
NamePart
(type = family)
Wang
NamePart
(type = given)
Ruolin
NamePart
(type = date)
1990-
DisplayForm
Ruolin Wang
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
HO
NamePart
(type = given)
CHI-TANG
DisplayForm
CHI-TANG HO
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
HUANG
NamePart
(type = given)
QINGRONG
DisplayForm
QINGRONG HUANG
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Hartman
NamePart
(type = given)
Thomas G.
DisplayForm
Thomas G. Hartman
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(encoding = w3cdtf);
(qualifier = exact)
2015
DateOther
(qualifier = exact);
(type = degree)
2015-10
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Polymethoxyflavones (PMFs) are a group of flavonoids found exclusively in citrus genus that have been identified with many potent biological activities, including anti-inflammation, anti-cancer, anti-atherosclerosis, and antioxidant. However, the bioavailability of PMFs is seldom studied. As far as we know, PMFs have poor aqueous solubility, and may potentially have high permeability due to their lipophilic structure. Biological studies rely on efficient separation method to obtain pure compounds. Silica gel column chromatography was utilized in this study to separate individual PMFs from aged orange peel extracts, and the yielded products had more than 95% purity. With this established method, purified PMF derivatives from chemical modification were also obtained. In this research, we systemically investigated permeability and solubility of totally six PMFs and their derivatives, namely, sinensetin (SIN), 5-hydroxy-sinensetin (5-OH-SIN), 5-acetyl-sinensetin (5-Ac-SIN), 3,5,6,7,8,3’,4’-Heptamethoxyflavone (HeptaMF), 5-hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone (5-OH-HeptaMF), and 5-acetyl-3,6,7,8,3’,4’-hexamethoxyflavone (5-Ac-HeptaMF). Among them, 5-OH-SIN, 5-Ac-SIN, and 5-Ac-HeptaMF were prepared via chemical modification. From the octanol/water solubility test, it was found that PMFs and their derivatives had very low aqueous solubility. Permeability experiment via Caco-2 cell monolayer transport model was conducted indicating high permeability of all the tested compounds. Furthermore, PMFs had the greatest permeability, followed by 5-acetyl PMFs and 5-hydroxy PMFs. Moreover, metabolism especially deacetylation was observed during the transport of 5-acetyl PMFs. Considering permeability and solubility together, PMFs and their derivatives are expected having good absorption. This study gives indicative information on the bioavailability of PMFs and their derivatives, which provides clues on the application of PMFs in functional food or nutraceutical products.
Subject
(authority = RUETD)
Topic
Food Science
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6712
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 102 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Orange peel
Subject
(authority = ETD-LCSH)
Topic
Citrus
Subject
(authority = ETD-LCSH)
Topic
Flavonoids
Note
(type = statement of responsibility)
by Ruolin Wang
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3MS3VSD
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Wang
GivenName
Ruolin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-09-07 23:36:57
AssociatedEntity
Name
Ruolin Wang
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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Statistical Profile