Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules
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Anand, Prachi S.. Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules. Retrieved from https://doi.org/doi:10.7282/T30R9RDK
TitleSurface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules
DescriptionDynamic surfaces can be customized to form a multifunctional assembly that favors the adsorption of the proteins and the sugar molecules in a one pot reaction and provides a control over the orientation and conformation of the bioactive ligands on the synthetic surface. Self-assembled monolayers SAMs), bearing bifunctional groups grant a straightforward, flexible and simplistic method to overcome the limitations posed by a biopolymer-peptide system. These bifunctional moieties on one terminus can be adhered to the synthetic biopolymer that acts as a scaffold for the assembly and on the other terminus can be tailored to attach to highly specific biomolecules such as peptides and carbohydrates . In a novel synthesis, the SAMs can be attached to the different biomolecules by multicomponent reactions (MCR). MCRs are the chemical reactions in which three or more reactants form a product. Although, these reactions have been known for a long time, but have yet to be used in the synthesis of the biological components that mimic the extracellular matrix (ECM).