Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules
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Title
Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules
Dynamic surfaces can be customized to form a multifunctional assembly that favors the adsorption of the proteins and the sugar molecules in a one pot reaction and provides a control over the orientation and conformation of the bioactive ligands on the synthetic surface. Self-assembled monolayers SAMs), bearing bifunctional groups grant a straightforward, flexible and simplistic method to overcome the limitations posed by a biopolymer-peptide system. These bifunctional moieties on one terminus can be adhered to the synthetic biopolymer that acts as a scaffold for the assembly and on the other terminus can be tailored to attach to highly specific biomolecules such as peptides and carbohydrates . In a novel synthesis, the SAMs can be attached to the different biomolecules by multicomponent reactions (MCR). MCRs are the chemical reactions in which three or more reactants form a product. Although, these reactions have been known for a long time, but have yet to be used in the synthesis of the biological components that mimic the extracellular matrix (ECM).
Subject (authority = RUETD)
Topic
Chemistry
Subject (authority = ETD-LCSH)
Topic
Biomolecules
Subject (authority = ETD-LCSH)
Topic
Adhesion
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6561
PhysicalDescription
Form (authority = gmd)
electronic resource
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application/pdf
InternetMediaType
text/xml
Note
Supplementary File: Prachi Anand_MS thesis 2015
Extent
1 online resource (iv, 19 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Prachi S. Anand
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.