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The maternal immune system during pregnancy and its influence on fetal development

Descriptive

TypeOfResource
Text
TitleInfo
Title
The maternal immune system during pregnancy and its influence on fetal development
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Pathology & Laboratory Medicine (New Jersey Medical School, NJMS)
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
New Jersey Medical School (NJMS)
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Pharmacology and Toxicology
Name (type = corporate); (authority = RutgersOrg-School)
NamePart
Ernest Mario School of Pharmacy
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (qualifier = exact); (keyDate = yes)
2015
Abstract (type = Abstract)
The maternal immune system plays a critical role in the establishment, maintenance, and completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve these goals are not well understood. Various cells and molecules of the immune system are key players in the development and function of the placenta and the fetus. Effector cells of the immune system act to promote and yet limit placental development. The T helper 1 (Th1)/T helper 2 (Th2) immune shift during pregnancy is well established. A fine balance between proinflammatory and anti-inflammatory influences is required. We herein review the evidence regarding maternal tolerance of fetal tissues and the underlying cell-mediated immune and humoral (hormones and cytokines) mechanisms. We also note the many unanswered questions in our understanding of these mechanisms. In addition, we summarize the clinical manifestations of an altered maternal immune system during pregnancy related to susceptibility to common viral, bacterial, and parasitic infections, as well as to autoimmune diseases.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
19 p.
Subject (authority = local)
Topic
Maternal–fetal interface
Subject (authority = LCSH)
Topic
Maternal-fetal exchange
Subject (authority = LCSH)
Topic
Immune system
Subject (authority = local)
Topic
Fetal tolerance
Subject (authority = LCSH)
Topic
Lymphocytes
Subject (authority = local)
Topic
Lymphocyte subsets
Subject (authority = LCSH)
Topic
Decidua
Subject (authority = LCSH)
Topic
Pregnancy
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2015
AssociatedObject
Name
Research and Reports in Biology
Type
Journal
Relationship
Has part
Detail
171-189
Identifier (type = volume and issue)
6,
Reference (type = url)
http://dx.doi.org/10.2147/RRB.S80652
Name (type = personal)
NamePart (type = family)
Morelli
NamePart (type = given)
Sara S.
Affiliation
Obstetrics, Gynecology and Women's Health, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Mandal
NamePart (type = given)
Mili
Affiliation
Pharmacology and Toxicology, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Goldsmith
NamePart (type = given)
Laura T.
Affiliation
Obstetrics, Gynecology and Women's Health, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Kashani
NamePart (type = given)
Banafsheh N.
Affiliation
Obstetrics, Gynecology and Women's Health, Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Ponzio
NamePart (type = given)
Nicholas M.
Affiliation
Pathology & Laboratory Medicine (New Jersey Medical School, NJMS), Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
RelatedItem (type = host)
TitleInfo
Title
Ponzio, Nicholas M.
Identifier (type = local)
rucore30184800001
RelatedItem (type = host)
TitleInfo
Title
Goldsmith, Laura T.
Identifier (type = local)
rucore30192100001
RelatedItem (type = host)
TitleInfo
Title
Morelli, Sara S.
Identifier (type = local)
rucore30192200001
RelatedItem (type = host)
TitleInfo
Title
Kashani, Banafsheh N.
Identifier (type = local)
rucore30192300001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30C4XRF
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsHolder (type = personal)
Name
FamilyName
Morelli
GivenName
Sara
MiddleName
S.
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Mandal
GivenName
Mili
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Goldsmith
GivenName
Laura
MiddleName
T.
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Kashani
GivenName
Banafsheh
MiddleName
N.
Role
Copyright holder
RightsHolder (type = personal)
Name
FamilyName
Ponzio
GivenName
Nicholas
MiddleName
M.
Role
Copyright holder
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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