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Association of cervical microglandular hyperplasia with exogenous progestin exposure

Descriptive

TypeOfResource
Text
TitleInfo
Title
Association of cervical microglandular hyperplasia with exogenous progestin exposure
Name (type = personal)
NamePart (type = family)
Heller
NamePart (type = given)
Debra
Affiliation
Pathology & Laboratory Medicine (New Jersey Medical School, NJMS), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Nguyen
NamePart (type = given)
Lena
Affiliation
Obstetrics, Gynecology & Women's Health, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Goldsmith
NamePart (type = given)
Laura T.
Affiliation
Obstetrics, Gynecology & Women's Health, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Pathology & Laboratory Medicine (New Jersey Medical School, NJMS)
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Obstetrics, Gynecology & Women's Health
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Non-refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = no); (qualifier = exact)
2015
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2016
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
10 p.
Subject (authority = LCSH)
Topic
Cervix uteri
Subject (authority = LCSH)
Topic
Hyperplasia
Subject (authority = LCSH)
Topic
Women--Health and hygiene
Note (type = peerReview)
Peer reviewed
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Type
Journal
Relationship
Has part
Name
Journal of Lower Genital Tract Disease
Reference (type = url)
http://dx.doi.org/10.1097/LGT.0000000000000176
Identifier (type = volume and issue)
20(2)
Detail
162-164
Abstract (type = abstract)
Objectives: Although microglandular hyperplasia is a benign endocervical lesion, it may raise concern of malignancy in an inexperienced pathologist, because clinicians may not be familiar with it on a report. It has been reported to occur in association with progestational stimulation, but this has not been well studied. The aim of the study was to evaluate this potential association.

Materials and Methods: This was an observational case control study of patients seen from January 01, 1991 to November 01, 2014 at the University Hospital, Newark, New Jersey. Cases of microglandular hyperplasia and controls were identified from the files of the Department of Pathology. Controls were cases of endocervical curettages for whom no microglandular hyperplasia was detected. Medical records were reviewed for evidence of exogenous progestin exposure within the previous 6 months.

Results: Eighty-nine cases of microglandular hyperplasia and 97 controls were identified. Of the cases of microglandular hyperplasia, 26 (29.2%) of 89 cases had exposure to progestational medication, significantly greater than that of controls (10/97, 10.3%; p = .0014).

Conclusions: Our data show that a significantly higher percentage of women with microglandular hyperplasia had progestin exposure than women who do not exhibit this benign lesion. Clinicians and pathologists should be aware of this association, as well as the benign nature of the lesion.
RelatedItem (type = host)
TitleInfo
Title
Heller, Debra
Identifier (type = local)
rucore30185000001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3862JG9
Genre (authority = ExL-Esploro)
Accepted Manuscript
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004); (TYPE = [FS] statement #1)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = start)
2016-01-26
DateTime (encoding = w3cdtf); (point = end)
2017-04-30
Detail
Access to this PDF has been restricted at the publisher's request. The publisher, Wolters Kluwer, requires a 12 month embargo from the date the article was published. The article in this repository will be publicly available after April 30, 2017.
RightsHolder (type = corporate)
Name
American Society for Colposcopy and Cervical Pathology
Role
Copyright holder
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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