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Functional Reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms

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TypeOfResource
Text
TitleInfo
Title
Functional Reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms
Name (type = personal)
NamePart (type = family)
Yu
NamePart (type = given)
Jiandong
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Proddutur
NamePart (type = given)
Archana
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Swietek
NamePart (type = given)
Bogumila
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Elgammal
NamePart (type = given)
Fatima S.
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Santhakumar
NamePart (type = given)
Viji
Affiliation
Pharmacology & Physiology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Pharmacology & Physiology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
New Jersey Medical School (NJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = no); (qualifier = exact)
2015
DateIssued (encoding = w3cdtf); (keyDate = yes)
2016
Abstract (type = Abstract)
Strong perisomatic inhibition by fast-spiking basket cells (FS-BCs) regulates dentate throughput. Homotypic FS-BC interconnections that support gamma oscillations, and heterotypic inputs from diverse groups of interneurons that receive extensive neurochemical regulation, together, shape FS-BC activity patterns. However, whether seizures precipitate functional changes in inhibitory networks and contribute to abnormal network activity in epilepsy is not known. In the first recordings from dentate interneuronal pairs in a model of temporal lobe epilepsy, we demonstrate that status epilepticus (SE) selectively compromises GABA release at synapses from dentate accommodating interneurons (AC-INs) to FS-BCs, while efficacy of homotypic FS-BC synapses is unaltered. The functional decrease in heterotypic cannabinoid receptor type 1 (CB<sub>1</sub>R)-sensitive inhibition of FS-BCs resulted from enhanced baseline GABA<sub>B</sub>-mediated suppression of synaptic release after SE. The frequency of CB<sub>1</sub>R-sensitive inhibitory synaptic events in FS-BCs was depressed early after SE induction and remained reduced in epileptic rats. In biologically based simulations of heterogeneous inhibitory networks and excitatory-inhibitory cell networks, experimentally identified decrease in reliability of AC-IN to FS-BCs synaptic release reduced theta power and theta-gamma coupling and enhanced gamma coherence. Thus, the experimentally identified functional reduction in heterotypic inhibition of FS-BCs can contribute to compromised network oscillations in epilepsy and could precipitate memory and cognitive co-morbidities.
PhysicalDescription
InternetMediaType
application/pdf
Extent
63 p.
Extension
DescriptiveEvent
Type
Citation
AssociatedObject
Name
Cerebral Cortex
Type
Journal
Relationship
Has part
Reference (type = url)
http://dx.doi.org/10.1093/cercor/bhv199
Identifier (type = volume and issue)
26(11)
Detail
4299-4314
DateTime (encoding = w3cdtf)
2016
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Vijayalakshmi Santhakumar
AssociatedObject
Type
Grant number
Name
NS069861
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Epilepsy Foundation
AssociatedEntity
Role
Originator
Name
Jiandong Yu
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Subject (authority = local)
Topic
Cannabinoid
Subject (authority = local)
Topic
Dentate gyrus
Subject (authority = local)
Topic
Epilepsy
Subject (authority = local)
Topic
Interneuron
Subject (authority = local)
Topic
Oscillations
RelatedItem (type = host)
TitleInfo
Title
Santhakumar, Viji
Identifier (type = local)
rucore30192800001
RelatedItem (type = host)
TitleInfo
Title
Swietek, Bogumila
Identifier (type = local)
rucore30221700001
RelatedItem (type = host)
TitleInfo
Title
Proddutur, Archana
Identifier (type = local)
rucore30221600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3ZK5JP4
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
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RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
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