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Studies of viral tethering and its effect in the early phase of MLV life cycle
Descriptive
TitleInfo
Title
Studies of viral tethering and its effect in the early phase of MLV life cycle
Name
(type = personal)
NamePart
(type = family)
Addaquay
NamePart
(type = given)
Araba
NamePart
(type = date)
1981-
DisplayForm
Araba Addaquay
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Roth
NamePart
(type = given)
Monica
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Monica Roth
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
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(type = personal)
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(type = family)
Grant
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(type = given)
Barth
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Barth Grant
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Advisory Committee
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internal member
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(type = family)
ZARATEIGUI
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MIKEL
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MIKEL ZARATEIGUI
Affiliation
Advisory Committee
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internal member
Name
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Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
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Text
Genre
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theses
OriginInfo
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2016
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(type = degree)
2016-01
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2016
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The p12 proteins designed to encode peptide sequences from viral tethering proteins was shown to rescue murine leukemia virus (MLV) p12 PM14 lethal mutants (Schneider et al., 2013). However, the viral tethering protein from Kaposi’s sarcoma associated herpes virus (KSHV) latency-associated nuclear antigen encoding a nuclear localization signal, LANA(1-32), could not rescue MLV p12 PM14. This isolate p12 with LANA(1-32) fused to GFP was found to bind tightly to mitotic chromosomes. We show that virus bearing p12 LANA(1-32) PM14 retain the group-specific antigen (Gag) precursor inside the nucleus and that insertion of a nuclear export signal (NES) is able to counterbalance the effect of the NLS (nuclear localization signal). However, viral kinetics of MLV p12 LANA(1-32) PM14 with or without the NES indicates that the virus is still not viable. This suggests that the original hypothesis of the tight tethering domain that is p12 LANA(1-32) is detrimental to MLV infection.
Subject
(authority = RUETD)
Topic
Cell and Developmental Biology
Subject
(authority = ETD-LCSH)
Topic
Mouse leukemia viruses
Subject
(authority = ETD-LCSH)
Topic
Retroviruses
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_6991
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (v, 30 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Araba Addaquay
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(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T30R9RF1
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Addaquay
GivenName
Araba
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2016-01-10 15:15:08
AssociatedEntity
Name
ARABA ADDAQUAY
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
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2016-01-31
DateTime
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2016-08-01
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after August 1st, 2016.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
OperatingSystem
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windows xp
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