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Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens

Descriptive

TypeOfResource
Text
TitleInfo
Title
Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Biology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Camden College of Arts and Sciences
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2016
Abstract (type = Abstract)
During the infection process, pathogenic bacteria undergo large-scale transcriptional changes to promote virulence and increase intrahost survival. While much of this reprogramming occurs in response to changes in chemical environment, such as nutrient availability and pH, there is increasing evidence that adhesion to host-tissue can also trigger signal transduction pathways resulting in differential gene expression. Determining the molecular mechanisms of adhesion-mediated signaling requires disentangling the contributions of chemical and mechanical stimuli. Here we highlight recent work demonstrating that surface attachment drives a transcriptional response in bacterial pathogens, including uropathogenic Escherichia coli (E. coli), and discuss the complexity of experimental design when dissecting the specific role of adhesion-mediated signaling during infection.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
8 p.
Subject (authority = LCSH)
Topic
Adhesion
Subject (authority = LCSH)
Topic
Cellular signal transduction
Subject (authority = LCSH)
Topic
Virulence (Microbiology)
Subject (authority = local)
Topic
Uropathogenic E. coli
Subject (authority = LCSH)
Topic
Escherichia coli
Subject (authority = local)
Topic
Fimbriae
Subject (authority = LCSH)
Topic
Pili (Microbiology)
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
Pathogens
Type
Journal
Relationship
Has part
Identifier (type = volume and issue)
5(1)
Reference (type = url)
http://dx.doi.org/10.3390/pathogens5010023
Detail
23
Name (type = personal)
NamePart (type = family)
Moorthy
NamePart (type = given)
Sudha
Affiliation
Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Keklak
NamePart (type = given)
Julia
Affiliation
Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-3941-6233)
NamePart (type = family)
Klein
NamePart (type = given)
Eric A.
Affiliation
Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
RelatedItem (type = host)
TitleInfo
Title
Klein, Eric A.
Identifier (type = local)
rucore30196400001
RelatedItem (type = host)
TitleInfo
Title
Moorthy, Sudha
Identifier (type = local)
rucore30196700001
RelatedItem (type = host)
TitleInfo
Title
Keklak, Julia
Identifier (type = local)
rucore30196800001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T39Z96Z0
Genre (authority = ExL-Esploro)
Journal Article
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Publication notice
Detail
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons by Attribution
(CC-BY) license (http://creativecommons.org/licenses/by/4.0/)
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
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