Home
Resource
Triggered release of vancomycin to bacterial infection sites using pH-sensitive lipid based nanoparticles
PDF
PDF format is widely accepted and good for printing.
Plug-in required
PDF-1(2.00 MB)
Citation & Export
View Usage Statistics
Staff View

Citation & Export
Hide

Simple citation

Holleran, Timothy. Triggered release of vancomycin to bacterial infection sites using pH-sensitive lipid based nanoparticles. Retrieved from https://doi.org/doi:10.7282/T32809NQ

Export

Click here for information about Citation Management Tools at Rutgers.

Statistics
Hide

Description

TitleTriggered release of vancomycin to bacterial infection sites using pH-sensitive lipid based nanoparticles
NameHolleran, Timothy (author); Sofou, Stavroula (chair); Androulakis, Ioannis P (internal member); Berthiaume, Francois (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-01 (degree)
SubjectBiomedical Engineering, Vancomycin, Nanoparticles
Extent1 online resource (vii, 32 p. : ill.)
DescriptionThe appearance of resistant strains of bacteria in community healthcare facilities is a common occurrence with growing severity. Cases of resistance to β-lactam drugs such as Methicillin have been shown in Staphylococcus aureus (MRSA) and Staphylococcus epidermis (MRSE), among many others, and these resistances limit therapeutic options. The synthetic glycopeptide antibiotic Vancomycin is considered one of the last lines of defense for these types of resistant infections. Failures in antibiotic therapy at this stage come from inadequate drug concentration at the infected sites, reduction of activity due to local acidity, and toxicity associated with accumulation in non-infected tissue. To solve these issues, an environmentally-responsive lipid-based nanoparticle, or liposome, has been developed to deliver Vancomycin to local infection sites. These liposomes retain their drug contents at physiologic pH, increasing antibiotic circulation time. Additionally, they are selectively triggered to release their drug contents by the external stimulus of decreased pH of local infection sites. Encapsulation of Vancomycin in these liposomes was performed, showing stable retention and release between pH 7.4 and 5.5, respectively. Additionally, demonstration of the enhanced antibiotic activity of the pH-triggered nanoparticles was carried out through Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) studies. From the results, there is promising data suggesting that targeted delivery of Vancomycin using environmentally sensitive liposomes is a candidate for sustained and targeted antibiotic therapy in resistant bacterial infections.
NoteM.S.
NoteIncludes bibliographical references
Noteby Timothy Holleran
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T32809NQ
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
Version 8.5.5
Rutgers University Libraries - Copyright ©2024