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Characterization of zearalenone and its metabolites in older women and the relationship with food intake
Descriptive
TitleInfo
Title
Characterization of zearalenone and its metabolites in older women and the relationship with food intake
Name
(type = personal)
NamePart
(type = family)
Mauro
NamePart
(type = given)
Tara
NamePart
(type = date)
1990-
DisplayForm
Tara Mauro
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Shapses
NamePart
(type = given)
Sue A
DisplayForm
Sue A Shapses
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Bandera
NamePart
(type = given)
Elisa
DisplayForm
Elisa Bandera
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Schneider
NamePart
(type = given)
Stephen
DisplayForm
Stephen Schneider
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(encoding = w3cdtf);
(qualifier = exact)
2016
DateOther
(qualifier = exact);
(type = degree)
2016-01
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2016
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The environmental estrogen, zearalenone (ZEA), is found in the food supply from Fusarium fungal contamination in grains. Zeranol(Ralgro©), a synthetic form of the metabolite α-ZAL, is an FDA approved growth promoter for use in beef cattle. Animal studies have found ZEA to be associated with reproductive impairment. Circulating concentrations of ZEA and its metabolites (Z metabolites) [a-zearalenol, zeranol, b-zearalenol, b-zearalanol and zearalanone] have not been previously examined in adults and could have an estrogenic effect. The aim of this research was to characterize the free and total Z metabolite concentrations in human serum and urine samples, and determine associations with food intake. A cross-sectional analysis in 48 women (25-69 years, body mass index of 25 ± 5 kg/m2) was conducted. An HPLC/MS/MS technique analyzed for Z metabolites and an average of three 24-hour food diaries was used to assess intakes. Re-analysis of the metabolites was performed using more strict quantitative criteria. The total (free and conjugated) summed metabolite concentration for urine and serum was 43.8 ± 37.8 ng/mL and 1.8 ± 0.9 ng/mL, respectively. The detection of urinary Z metabolites ranged from 13-88% and 46-100% for free and total metabolites, respectively. In serum, detection ranged from 17-92% and 17-100% for free and total, respectively. ZEA showed the highest detection rate of all the Z metabolites in both serum and urine. Women with highest (10-17 oz/day) versus lowest (0-4 oz/day) meat intake had higher total serum Z metabolite concentrations (2.0 ± 0.9ng/mL) compared to those with low intakes (1.1± 0.8 ng/mL) (p<0.05). After re-analysis with more strict criteria, concentrations for urinary and serum total metabolites were 27.7 ± 22.2 ng/mL and 1.0 ± 0.7 ng/mL, respectively. The detection rates for urinary metabolites ranged from 2-88% (free) and 8-100% (total). Serum metabolite detection ranged from 2-45%(free) and 4-96%(total). Despite the lower detection rate and concentrations, the same significant relationship with meat intake remained. There is a wide range of ZEA and metabolites present in the serum and urine of adult women and total serum concentrations are associated with meat intake. More investigation into the effects of ZEA exposure in humans is necessary.
Subject
(authority = RUETD)
Topic
Nutritional Sciences
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6975
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 50 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Zeranol
Subject
(authority = ETD-LCSH)
Topic
Older women--Nutrition
Subject
(authority = ETD-LCSH)
Topic
Estrogen
Note
(type = statement of responsibility)
by Tara Mauro
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3PR7Z1K
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Mauro
GivenName
Tara
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2016-01-08 18:08:35
AssociatedEntity
Name
Tara Mauro
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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