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A parameter estimation approach to form a preliminary model describing the transcriptomic and proteomic dynamics in rat liver from a dose of corticosteroid
Descriptive
TitleInfo
Title
A parameter estimation approach to form a preliminary model describing the transcriptomic and proteomic dynamics in rat liver from a dose of corticosteroid
Name
(type = personal)
NamePart
(type = family)
Pai
NamePart
(type = given)
Jonathan
NamePart
(type = date)
1990-
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Jonathan Pai
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Androulakis
NamePart
(type = given)
Ioannis P.
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Ioannis P. Androulakis
Affiliation
Advisory Committee
Role
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chair
Name
(type = personal)
NamePart
(type = family)
Zhang
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(type = given)
Haoran
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Haoran Zhang
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Advisory Committee
Role
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outside member
Name
(type = personal)
NamePart
(type = family)
Vishnyakov
NamePart
(type = given)
Aleksey
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Aleksey Vishnyakov
Affiliation
Advisory Committee
Role
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outside member
Name
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Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
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Text
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theses
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2016
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(type = degree)
2016-01
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2016
Place
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(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Synthetic glucocorticoids are used widely in medicine for its effective anti-inflammatory and immunosuppressive effect. However, they have fairly negative adverse effects especially when used in the long term. Better understanding of the pharmacokinetics and pharmacodynamics (PK/PD) will provide better insights to their mechanism of action helping us to optimize its use as a clinical therapy. The onset of gene microarray presents quantitatively large data sets that can be very cumbersome to analyze. A parameter estimation approach using optimization methods can be used in order to help shape a PK/PD model for describing the transcriptomic and proteomic changes from CS. In this study, parameter estimation was used to form a preliminary model of the transcriptomic and proteomic gene interaction in rat liver from a dose of methylprednisolone (MPL), a commonly used synthetic glucocorticoid.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_6921
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 19 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Subject
(authority = ETD-LCSH)
Topic
Glucocorticoids
Note
(type = statement of responsibility)
by Jonathan Pai
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3X63Q1T
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Pai
GivenName
Jonathan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2015-12-16 15:29:18
AssociatedEntity
Name
Jonathan Pai
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ContentModel
ETD
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(VERSION = 5.1)
windows xp
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