A parameter estimation approach to form a preliminary model describing the transcriptomic and proteomic dynamics in rat liver from a dose of corticosteroid
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A parameter estimation approach to form a preliminary model describing the transcriptomic and proteomic dynamics in rat liver from a dose of corticosteroid
Synthetic glucocorticoids are used widely in medicine for its effective anti-inflammatory and immunosuppressive effect. However, they have fairly negative adverse effects especially when used in the long term. Better understanding of the pharmacokinetics and pharmacodynamics (PK/PD) will provide better insights to their mechanism of action helping us to optimize its use as a clinical therapy. The onset of gene microarray presents quantitatively large data sets that can be very cumbersome to analyze. A parameter estimation approach using optimization methods can be used in order to help shape a PK/PD model for describing the transcriptomic and proteomic changes from CS. In this study, parameter estimation was used to form a preliminary model of the transcriptomic and proteomic gene interaction in rat liver from a dose of methylprednisolone (MPL), a commonly used synthetic glucocorticoid.
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Chemical and Biochemical Engineering
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_6921
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (vi, 19 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Glucocorticoids
Note (type = statement of responsibility)
by Jonathan Pai
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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Rutgers University. Graduate School - New Brunswick
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.