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pH sensitive liposomes for targeted delivery of antibiotics to localized internal bacterial infection sites

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TitleInfo
Title
pH sensitive liposomes for targeted delivery of antibiotics to localized internal bacterial infection sites
Name (type = personal)
NamePart (type = family)
Rane
NamePart (type = given)
Varsha
NamePart (type = date)
1991-
DisplayForm
Varsha Rane
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Sofou
NamePart (type = given)
Stavroula
DisplayForm
Stavroula Sofou
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Roth
NamePart (type = given)
Charlie
DisplayForm
Charlie Roth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Androulakis
NamePart (type = given)
Ioannis
DisplayForm
Ioannis Androulakis
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Methicillin Resistant Staphylococcus aureus (MRSA) causes a myriad of infections ranging from mild skin-infection to more serious infections affecting internal organs. A glycopeptide, Vancomycin, remains the last line of defense against MRSA. The aim of this study is to investigate whether liposomal encapsulated Vancomycin had a better antimicrobial action than free Vancomycin in terms of infection-specific targeting and circulation time. For the same, encapsulation efficiency and release kinetics of the liposomes was evaluated along with Minimum Inhibitory Concentrations (MIC) of the liposomal preparations. The liposomes showcased a 12-15% encapsulation efficiency. Sustained release at pH 6.0 as compared to little to no release at pH 7.4 was demonstrated by the pH sensitive liposomes. Also, in acidic pH, an increase in efficacy was observed with a greater decrease in the MIC of the pH responsive liposomes as compared to the lower decrease in MIC of the non pH-responsive liposomes and increase in MIC of free Vancomycin. Thus, from the results it can be concluded that environmentally sensitive liposomes could be developed as a successful carrier of antimicrobial drugs demonstrating effective antimicrobial action.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = ETD-LCSH)
Topic
Liposomes
Subject (authority = ETD-LCSH)
Topic
Antibiotics
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7025
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 32 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Varsha Rane
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3MS3VV9
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Rane
GivenName
Varsha
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-01-14 16:50:06
AssociatedEntity
Name
VARSHA RANE
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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