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Controlled and sustained polymeric drug delivery systems for diabetic bone healing
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Yu, Weiling. Controlled and sustained polymeric drug delivery systems for diabetic bone healing. Retrieved from https://doi.org/doi:10.7282/T3FQ9ZPB

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TitleControlled and sustained polymeric drug delivery systems for diabetic bone healing
NameYu, Weiling (author); Uhrich, Kathryn (chair); Zahn, Jeffrey (internal member); Li, John (internal member); Olabisi, Ronke (internal member); Graves, Dana (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-01 (degree)
SubjectBiomedical Engineering, Drug delivery systems, Diabetes--Treatment
Extent1 online resource (xxii, 120 p. : ill.)
DescriptionDiabetes involves chronic metabolic changes that can impair bone healing, including a prolonged inflammatory response after injury and changes in gene expressions of cells involved in bone healing. In this thesis, various controlled and sustained polymeric drug delivery systems were developed to enhance diabetic bone healing. First, a salicylic acid (SA)-based poly(anhydride ester) (SAPAE) that releases SA in a sustained and controlled manner was observed to mitigate local inflammation and significantly enhanced bone regeneration in diabetic rats. Second, insulin-encapsulating SAPAE microspheres were formulated to co-deliver SA and insulin, which are both active compounds for diabetic bone healing with clinically proven synergistic effects. Bulk double-emulsion and microfluidic techniques were both utilized to form the microspheres. The bulk method gives higher microsphere productivity, whereas the microfluidic method offers smaller microsphere size variance. Lastly, SAPAE porous scaffolds were formed to possess the desired SA release profile and porosity for diabetic bone healing – combining both the chemical and physical advantages. These studies centered on controlled and sustained drug delivery systems for diabetic bone healing and utilized different formulation techniques to add favorable properties to the systems. With the unique properties of controlled and sustained SA release, the combination of multiple therapeutics (insulin and SA) and the integration of chemical and physical therapeutic properties (SA release and scaffold porosity), these systems are promising treatments or co-treatments for diabetic bone healing.
NotePh.D.
NoteIncludes bibliographical references
Noteby Weiling Yu
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3FQ9ZPB
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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