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Controlled and sustained polymeric drug delivery systems for diabetic bone healing

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TitleInfo
Title
Controlled and sustained polymeric drug delivery systems for diabetic bone healing
Name (type = personal)
NamePart (type = family)
Yu
NamePart (type = given)
Weiling
NamePart (type = date)
1988-
DisplayForm
Weiling Yu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Uhrich
NamePart (type = given)
Kathryn
DisplayForm
Kathryn Uhrich
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Zahn
NamePart (type = given)
Jeffrey
DisplayForm
Jeffrey Zahn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Li
NamePart (type = given)
John
DisplayForm
John Li
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Olabisi
NamePart (type = given)
Ronke
DisplayForm
Ronke Olabisi
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Graves
NamePart (type = given)
Dana
DisplayForm
Dana Graves
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-01
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Diabetes involves chronic metabolic changes that can impair bone healing, including a prolonged inflammatory response after injury and changes in gene expressions of cells involved in bone healing. In this thesis, various controlled and sustained polymeric drug delivery systems were developed to enhance diabetic bone healing. First, a salicylic acid (SA)-based poly(anhydride ester) (SAPAE) that releases SA in a sustained and controlled manner was observed to mitigate local inflammation and significantly enhanced bone regeneration in diabetic rats. Second, insulin-encapsulating SAPAE microspheres were formulated to co-deliver SA and insulin, which are both active compounds for diabetic bone healing with clinically proven synergistic effects. Bulk double-emulsion and microfluidic techniques were both utilized to form the microspheres. The bulk method gives higher microsphere productivity, whereas the microfluidic method offers smaller microsphere size variance. Lastly, SAPAE porous scaffolds were formed to possess the desired SA release profile and porosity for diabetic bone healing – combining both the chemical and physical advantages. These studies centered on controlled and sustained drug delivery systems for diabetic bone healing and utilized different formulation techniques to add favorable properties to the systems. With the unique properties of controlled and sustained SA release, the combination of multiple therapeutics (insulin and SA) and the integration of chemical and physical therapeutic properties (SA release and scaffold porosity), these systems are promising treatments or co-treatments for diabetic bone healing.
Subject (authority = RUETD)
Topic
Biomedical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_6882
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxii, 120 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
Subject (authority = ETD-LCSH)
Topic
Diabetes--Treatment
Note (type = statement of responsibility)
by Weiling Yu
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3FQ9ZPB
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Yu
GivenName
Weiling
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2015-11-13 12:07:37
AssociatedEntity
Name
Weiling Yu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-01-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2017-01-30
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 30th, 2017.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
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