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Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing

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TypeOfResource
Text
TitleInfo
Title
Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0001-8417-8284)
NamePart (type = family)
Razavi
NamePart (type = given)
Sonia M.
Affiliation
Graduate School—New Brunswick, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Callegari
NamePart (type = given)
Gerardo
Affiliation
Engineering Research Center for Structured Organic Particulate Systems (C-SOPS)
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-3860-7329)
NamePart (type = family)
Drazer
NamePart (type = given)
German
Affiliation
Mechanical and Aerospace Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-5180-9147)
NamePart (type = family)
Cuitino
NamePart (type = given)
Alberto M.
Affiliation
Mechanical and Aerospace Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Mechanical and Aerospace Engineering
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Engineering Research Center for Structured Organic Particulate Systems (C-SOPS)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Graduate School--New Brunswick
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateIssued (encoding = w3cdtf)
2016
Abstract (type = Abstract)
An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate were manufactured continuously and in batches. The effect of two processing parameters, compaction force and level of shear strain were examined. Young's modulus and tensile strength of tablets were obtained by ultrasound and diametrical mechanical testing, respectively. It was found that as the blend was exposed to increasing levels of shear strain, the speed of sound in the tablets decreased and the tablets became both softer and mechanically weaker. Moreover, the results indicate that two separate tablet material properties (e.g., relative density and Young's modulus) are necessary in order to predict tensile strength. A strategy for hardness prediction is proposed that uses the existing models for Young's modulus and tensile strength of porous materials. Ultrasound testing was found to be very sensitive in differentiating tablets with similar formulation but produced under different processing conditions (e.g., different level of shear strain), thus, providing a fast, and non-destructive method for hardness prediction that could be incorporated to a continuous manufacturing process.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
15 p.
Subject (authority = local)
Topic
Tensile strength
Subject (authority = local)
Topic
Young's modulus
Subject (authority = local)
Topic
Ultrasound
Subject (authority = local)
Topic
Mechanical properties
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
International Journal of Pharmaceutics
Type
Journal
Relationship
Has part
Detail
83-89
Identifier (type = volume and issue)
507(1-2)
Reference (type = url)
http://dx.doi.org/10.1016/j.ijpharm.2016.04.064
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedObject
Type
Grant number
Name
IIP-1237873
RelatedItem (type = host)
TitleInfo
Title
Razavi, Sonia M.
Identifier (type = local)
rucore30208600001
RelatedItem (type = host)
TitleInfo
Title
Callegari, Gerardo
Identifier (type = local)
rucore30209000001
RelatedItem (type = host)
TitleInfo
Title
Drazer, German
Identifier (type = local)
rucore30143000001
RelatedItem (type = host)
TitleInfo
Title
Cuitino, Alberto M.
Identifier (type = local)
rucore30158900001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T35Q4Z74
Genre (authority = ExL-Esploro)
Accepted Manuscript
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (point = start); (encoding = w3cdtf)
2016-05-05
DateTime (point = end); (encoding = w3cdtf)
2017-05-04
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after May 4, 2017.
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.7
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-05-26T15:36:18
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-05-27T15:37:25
ApplicationName
Acrobat Distiller 9.0.0 (Windows)
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