Staff View
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures

Descriptive

TypeOfResource
Text
TitleInfo
Title
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Mechanical and Aerospace Engineering
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Chemical & Biochemical Engineering
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
OriginInfo
DateIssued (encoding = w3cdtf)
2016
Abstract (type = Abstract)
A full factorial design of experiments was used to study the effect of blend shear strain on the compaction process, relative density and strength of pharmaceutical tablets. The powder blends were subjected to different shear strain levels (integral of shear rate with respect to time) using an ad hoc Couette shear cell. Tablets were compressed at different compaction forces using an instrumented compactor simulator, and compaction curves showing the force-displacement profiles during compaction were obtained. Although the die-fill blend porosity (initial porosity) and the minimum in-die tablet porosity (at maximum compaction) decreased significantly with shear strain, the final tablet porosity was surprisingly independent of shear strain. The increase in the in-die maximum compaction with shear strain was, in fact, compensated during post-compaction relaxation of the tables, which also increased significantly with shear strain. Therefore, tablet porosity alone was not sufficient to predict tablet tensile strength. A decrease in the ‘work of compaction’ as a function of shear strain, and an increase in the recovered elastic work was observed, which suggested weaker particle-particle bonding as the shear strain in- creased. For each shear strain level, the Ryskewitch Duckworth equation was a good fit to the tensile strength as a function of tablet porosity, and the obtained asymptotic tensile strength at zero porosity exhibited a 60% reduction as a function of shear strain. This was consistent with a reduced bonding efficiency as the shear strain increased.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
23 p.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2016
AssociatedObject
Name
Powder Technology
Type
Journal
Relationship
Has part
Detail
657-664
Identifier (type = volume and issue)
301,
Reference (type = url)
http://dx.doi.org/10.1016/j.powtec.2016.05.058
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Science Foundation
AssociatedEntity
Role
Originator
Name
Alberto Cuitino
AssociatedObject
Type
Grant number
Name
IIP-1237873
Subject (authority = local)
Topic
Tensile strength
Subject (authority = local)
Topic
Porosity
Subject (authority = local)
Topic
Shear strain
Subject (authority = local)
Topic
Magnesium stearate
Subject (authority = local)
Topic
Compaction
Subject (authority = local)
Topic
Pharmaceutical tablets
Name (type = personal)
NamePart (type = family)
Pawar
NamePart (type = given)
Pallavi
Affiliation
Chemical & Biochemical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Joo
NamePart (type = given)
Hee
Affiliation
Chemical & Biochemical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Callegari
NamePart (type = given)
Gerardo
Affiliation
Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-3860-7329)
NamePart (type = family)
Drazer
NamePart (type = given)
German
Affiliation
Mechanical and Aerospace Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0002-5180-9147)
NamePart (type = family)
Cuitino
NamePart (type = given)
Alberto M.
Affiliation
Mechanical and Aerospace Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Muzzio
NamePart (type = given)
Fernando J.
Affiliation
Chemical & Biochemical Engineering, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
RelatedItem (type = host)
TitleInfo
Title
Drazer, German
Identifier (type = local)
rucore30143000001
RelatedItem (type = host)
TitleInfo
Title
Pawar, Pallavi
Identifier (type = local)
rucore30208500001
RelatedItem (type = host)
TitleInfo
Title
Joo, Hee
Identifier (type = local)
rucore30208900001
RelatedItem (type = host)
TitleInfo
Title
Callegari, Gerardo
Identifier (type = local)
rucore30209000001
RelatedItem (type = host)
TitleInfo
Title
Cuitino, Alberto M.
Identifier (type = local)
rucore30158900001
RelatedItem (type = host)
TitleInfo
Title
Muzzio, Fernando J.
Identifier (type = local)
rucore30209100001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3X63Q3Q
Note (type = peerReview)
Peer reviewed.
Back to the top

Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (point = start)
2016-11-01
DateTime (encoding = w3cdtf); (point = end)
2017-10-31
Detail
Access to this PDF has been restricted at the publisher's request. It will be publicly available after October 31, 2017.
RightsEvent
Type
Permission research
DateTime (encoding = w3cdtf)
2016-07-21
AssociatedEntity
Role
Librarian
Name
Jane Otto
Detail
"Green open access - Authors who are funded and report on research funded by a US federal agency are able to self-archive their accepted manuscript after a 12 month embargo." Retrieved from https://www.elsevier.com/about/open-science/open-access/agreements, July 21, 2016
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.4
ApplicationName
Mac OS X 10.11.5 Quartz PDFContext
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-07-18T18:17:08
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-07-18T18:17:08
Back to the top
Version 8.3.10
Rutgers University Libraries - Copyright ©2019