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Maternal T cell immune activation and postnatal stress

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TitleInfo
Title
Maternal T cell immune activation and postnatal stress
SubTitle
a two hit mouse nodel of schizophrenia
Name (type = personal)
NamePart (type = family)
Fox
NamePart (type = given)
Nicholas W.
NamePart (type = date)
1987-
DisplayForm
Nicholas W. Fox
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander W
DisplayForm
Alexander W Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Matzel
NamePart (type = given)
Louis
DisplayForm
Louis Matzel
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Wagner
NamePart (type = given)
George
DisplayForm
George Wagner
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Prenatal maternal immune activation (MIA) is a risk factor for several psychopathologic disorders, including bipolar disorder, autism, and schizophrenia. Most research has focused on using toll-like receptor agonists such as lipopolysaccharide or the synthetic viral genome analogue polyinosinic:polycytidylic acid as experimental immune activators. Little is known about how T cells, necessary for successful clearance of viruses and bacteria, may influence the neurodevelopment of the gestating fetus. Additionally, MIA has been implicated as the first hit in a two-hit hypothesis of schizophrenia development when coupled with a secondary insult, such as psychological stress, during adolescent neurodevelopment. To this end, I challenged pregnant C57BL/6J mice on day E12.5 of gestation with 200ug/kg of purified staphylococcal enterotoxin A (SEA), a potent superantigen, to oligoclonally activate maternal T cells. After birth, both male and female offspring were randomized into “stress” or “no stress” groups, where “stress” animals would experience a 14 day battery of mild, unpredictable stressors. All animals were then tested for spatial navigation in a water radial arm maze (wRAM), anxiety-like behavior in the elevated plus maze (EPM) and open-field, and sensorimotor gating, as measured by prepulse inhibition (PPI). In the wRAM, during hidden platform training, SEA-No Stress animals took significantly longer to find the escape platform and traveled significantly farther before finding it. SEA-No Stress animals also had a significantly higher number of fail errors, where they did not find the platform within 60 seconds. When testing for spatial memory, SEA-Stress animals spent the least amount of time in the platform arm, as well as taking significantly longer to make first entry. Stressed animals traveled further total distance in both the EPM and open field. Animals from SEA treated mothers spent less time investigating a novel object in the open field, as well as spent more time on the perimeter of the maze. No differences were observed between animals in PPI. Together, these findings suggest that specific T cell activation during pregnancy alters behavioral development in the offspring. Additionally, adolescent stress does not have an additive effect on prenatal SEA treatment, but rather combines to form a unique phenotype.
Subject (authority = RUETD)
Topic
Psychology
Subject (authority = ETD-LCSH)
Topic
T cells--Immunology
Subject (authority = ETD-LCSH)
Topic
Schizophrenia
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7093
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 56 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Nicholas W. Fox
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30G3N9Z
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Fox
GivenName
Nicholas
MiddleName
W.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-03-30 21:13:09
AssociatedEntity
Name
Nicholas Fox
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2016-04-29T23:10:57
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2016-04-29T23:10:57
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