DescriptionUnderstanding the interior workings of buildings has become an increasingly important research topic as a growing population of people is living in urbanized environments. Infrared thermography has been used extensively for detecting building defects that affect energy performance. The focus of this project not only concerns building energy performance but also health and structure hazards. The first objective of this research study is to review the use of infrared thermography for building performance inspection and synthesize findings from existing studies to demonstrate the potential of infrared thermography for detecting and quantifying health and structure hazards. The second objective of this research study is to explore the effectiveness of integration of infrared thermography and spatial sensing methods for intelligent building hazard detection and evaluation. The proposed research methodology involves several major components including design of data collection protocols, data fusion and intelligent extraction of building hazard related attributes, and field validation of proposed methods. The study was validated by surveying the health and safety performance of two multi-family buildings in a densely populated city in the Northeastern US, using the developed appraisal method that integrate infrared thermography with 3D point cloud data. The efficacy of integrated laser scanning and thermal imaging to determine housing-related health and structure-related issue was assessed. It is important to note that the research results reported in this study is part of a larger research effort aimed at developing quantitative understanding on the correlation between the defects inside the residential building and how they impact the residents’ health and comfort in a systemic way.