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The effects of exercise and estrogen on gut microbiota in female mice

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TitleInfo
Title
The effects of exercise and estrogen on gut microbiota in female mice
Name (type = personal)
NamePart (type = family)
Melvin
NamePart (type = given)
Rebecca
NamePart (type = date)
1992-
DisplayForm
Rebecca Melvin
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Campbell
NamePart (type = given)
Sara C.
DisplayForm
Sara C. Campbell
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
The gut microbiota has recently been acknowledged as having an impact on overall systemic health and obesity. To date, research has primarily focused on male mice due to the unknown effects of the menstrual cycle in females. Exercise is a known mediator of obesity related diseases, and the literature demonstrates an effect on the microbiome in males thus far. As post-menopausal obesity continues to rise, there is a need to explore the relationship between estrogen and the microbiome, with exercise as a possible moderator. In this study, female mice either had an ovariectomy, to simulate estrogen deficiency, or a sham procedure. Mice were placed into either a continuous exercise group, high intensity, or sedentary control group for six weeks. Microbial analysis was completed to view differences between groups. The estrogen deficient group had higher body weight and body fat percentages, regardless of exercise. Microbial analysis indicated a decrease in diversity in the estrogen deficient group, as well as a higher Firmicutes/Bacteriodetes ratio. These results are similar to obesity studies, suggesting that changes in the microbiome may be one mechanism that promotes obesity in the estrogen deficient state. Exercise interventions increased microbial diversity, with a higher percent of Bacteroidetes compared to Firmicutes.
Subject (authority = RUETD)
Topic
Kinesiology and Applied Physiology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7220
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 27 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Digestive organs--Microbiology
Subject (authority = ETD-LCSH)
Topic
Estrogen
Note (type = statement of responsibility)
by Rebecca Melvin
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3H1346K
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Melvin
GivenName
Rebecca
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-04-14 09:39:55
AssociatedEntity
Name
Rebecca Melvin
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2016-04-14T09:38:10
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2016-04-14T09:38:10
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