DescriptionDrug carriers are designed with an aim of decent pharmacokinetics and interaction with various nanoparticles. Several characteristics of drug carriers like shape and size influence the pharmacokinetics and interaction. To understand the factors that affect the morphology and dynamics of the system, we design coarse-grained models for the constituents of the carriers. Capturing the physical phenomena would require a molecular simulation technique capable of resolving over a vast ranges of space and time. Disssipative Particle dynamics (DPD) is one such technique which can simultaneously resolve molecular and continuum scales. This technique can handle large length (from 1 nm up to 1 μm) and time scales (nano-seconds to micro-seconds). This thesis focuses on understanding the underlying mechanisms that affect the organization, shape, stiffness and interfacial stability of biomaterials. This will help design simple biomimetic macromolecules finding use in delivery of therapeutic agents and cellular sensing. It also helps in understanding the underlying mechanisms of interactions between micelles, proteins or synthetic particles with bio-inspired macromolecules.