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Mesoscale modeling of biomimetic macromolecular aggregates

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TitleInfo
Title
Mesoscale modeling of biomimetic macromolecular aggregates
Name (type = personal)
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Uppaladadium
NamePart (type = given)
Geetartha
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Geetartha Uppaladadium
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author
Name (type = personal)
NamePart (type = family)
Dutt
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Meenakshi
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Meenakshi Dutt
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Advisory Committee
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chair
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Roth
NamePart (type = given)
Charles M
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Charles M Roth
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Advisory Committee
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internal member
Name (type = personal)
NamePart (type = family)
Chundawat
NamePart (type = given)
Shishir
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Shishir Chundawat
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
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school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Drug carriers are designed with an aim of decent pharmacokinetics and interaction with various nanoparticles. Several characteristics of drug carriers like shape and size influence the pharmacokinetics and interaction. To understand the factors that affect the morphology and dynamics of the system, we design coarse-grained models for the constituents of the carriers. Capturing the physical phenomena would require a molecular simulation technique capable of resolving over a vast ranges of space and time. Disssipative Particle dynamics (DPD) is one such technique which can simultaneously resolve molecular and continuum scales. This technique can handle large length (from 1 nm up to 1 μm) and time scales (nano-seconds to micro-seconds). This thesis focuses on understanding the underlying mechanisms that affect the organization, shape, stiffness and interfacial stability of biomaterials. This will help design simple biomimetic macromolecules finding use in delivery of therapeutic agents and cellular sensing. It also helps in understanding the underlying mechanisms of interactions between micelles, proteins or synthetic particles with bio-inspired macromolecules.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
Identifier
ETD_7208
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiv, 71 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Macromolecules
Subject (authority = ETD-LCSH)
Topic
Drug delivery systems
Note (type = statement of responsibility)
by Geetarthat Uppaladadium
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3KW5J6J
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Uppaladadium
GivenName
Geetartha
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-04-13 17:47:10
AssociatedEntity
Name
Geetartha Uppaladadium
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2016-04-15T04:46:31
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-04-15T04:46:31
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