Staff View
Determination of endocrine disruption risk following exposure to betamethasone in surface and drinking water

Descriptive

TitleInfo
Title
Determination of endocrine disruption risk following exposure to betamethasone in surface and drinking water
Name (type = personal)
NamePart (type = family)
Vestel
NamePart (type = given)
Jessica
NamePart (type = date)
1987-
DisplayForm
Jessica Vestel
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Hong
NamePart (type = given)
Jun-Yan
DisplayForm
Jun-Yan Hong
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Robson
NamePart (type = given)
Mark G.
DisplayForm
Mark G. Robson
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Meng
NamePart (type = given)
Qingyu
DisplayForm
Qingyu Meng
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Naumann
NamePart (type = given)
Bruce D.
DisplayForm
Bruce D. Naumann
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = personal)
NamePart (type = family)
Sargent
NamePart (type = given)
Edward V.
DisplayForm
Edward V. Sargent
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
To date, the presence of synthetic glucocorticosteroids in surface water and their potential endocrine disruption activity at environmental concentrations has not been fully investigated. Synthetic glucocorticosteroids (GC) may interfere with endogenous GC receptors within the hypothalamic-pituitary-gonadal (HPG) axis and disruptions of this pathway can result in decreased reproduction and/or adverse developmental effects in offspring. Much of the evidence for endocrine disruption in wildlife populations has been derived from aquatic animals such as fish, due to widespread contamination of surface water. The HPG axis is phylogenetically conserved across all vertebrate species and fish have the advantage over mammals as an experimental model of reaching maturity relatively quickly and have overall shorter life spans, which make them ideal for life cycle toxicology studies. Betamethasone, a synthetic glucocorticosteroid, has been on the market in the United States since the 1980’s and is on the World Health Organization Model List of Essential Medicines. Betamethasone mimics the action of cortisol and may disrupt the HPG axis. Studying fish for the endocrine disruption potential of betamethasone is logical, as they could be exposed to pharmaceuticals in waste water treatment plant effluent following normal patient use and excretion. In the present study, the Pharmaceutical Assessment and Transport Evaluation (PhATE) model estimated betamethasone concentrations to be <0.6 ng/L in 95% of all surface waters and <0.1 ng/L for 95% of the U.S. population. Environmentally relevant concentrations were then used in a two generation fish full life cycle (FFLC) study with Japanese medaka. Gross endpoints were evaluated, as well as secondary sexual characteristics and vitellogenin expression. The highest concentration at which no endocrine disruption outcomes are anticipated (NOEC) was determined to be 0.1 µg/L and a reference dose of 7 x 10-5 µg/kg-day for humans was derived from the NOEC. The average daily dose to humans was estimated from surface and drinking water concentrations and calculated margins of safety ranging from three to thirty indicate no adverse effects are anticipated from exposures to betamethasone at environmentally relevant concentrations.
Subject (authority = RUETD)
Topic
Public Health
Subject (authority = ETD-LCSH)
Topic
Drinking water--Contamination
Subject (authority = ETD-LCSH)
Topic
Endocrine disrupting chemicals
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7044
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xii, 104 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Jessica Vestel
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3G44SG4
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Vestel
GivenName
Jessica
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-02-26 08:49:09
AssociatedEntity
Name
Jessica Vestel
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
CreatingApplication
Version
1.4
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-03-31T11:28:35
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-03-31T11:28:35
Back to the top
Version 8.5.5
Rutgers University Libraries - Copyright ©2024