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Alleviation of metabolic syndrome by green tea polyphenol EGCG

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TitleInfo
Title
Alleviation of metabolic syndrome by green tea polyphenol EGCG
SubTitle
molecular mechanism involving amp-activated protein kinase
Name (type = personal)
NamePart (type = family)
Zhang
NamePart (type = given)
Le
NamePart (type = date)
1987-
DisplayForm
Le Zhang
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
yang
NamePart (type = given)
chung s
DisplayForm
chung s yang
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Zhou
NamePart (type = given)
Renping
DisplayForm
Renping Zhou
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Suh
NamePart (type = given)
Nanjoo
DisplayForm
Nanjoo Suh
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Metabolic syndrome (MetS) is a clustering of several cardiometabolic risk factors, including abdominal obesity, hyperglycemia, dyslipidemia and elevated blood pressure. More and more attention has been paid on MetS due to many reasons. For example, a quarter of the world’s adults have MetS, especially in developed countries; people with MetS has a five-fold greater risk of developing type II diabetes and three-times as likely to have a heart attack or stroke; and over 80% of the 200 million people with diabetes globally will die of cardiovascular diseases. In recent years, tea which is brewed from the plant Camellia sinensis has become increasingly popular for research because of its possible beneficial effects on human health, in particular in the area of MetS prevention. These beneficial qualities have mainly been attributed to catechins. In the present study, green tea polyphenols, Polyphenon E (PPE) and EGCG, were investigated in db/db and wild type mice to determine their effects on suppression of blood glucose level and activation of AMP-activated kinase (AMPK). Treatment of db/db mice with PPE (0.1% i.g.) or EGCG (200 or 400 mg/kg) decreased the level of blood glucose and increased the level of insulin both in blood or pancreas. Further, EGCG at 100, 200, and 400 mg/kg time- and dose-dependently up-regulated the phosphorylation of AMPK in liver, but it did not increase the oxidative stress. Melatonin, a strongly anti-oxidative compound, at 50 mg/kg (i.g.) was unable to block the effects of EGCG on activating AMPK. Together, these data suggest that green tea polyphenols or EGCG can alleviate MetS possibly through the activation of AMPK in liver, and the activation of AMPK by EGCG appears not to involve the reactive oxygen species in mice.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7259
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 55 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Metabolism--Disorders
Subject (authority = ETD-LCSH)
Topic
Green tea--Health aspects
Note (type = statement of responsibility)
by Le Zhang
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30R9RNQ
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Zhang
GivenName
Le
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-04-15 00:40:46
AssociatedEntity
Name
Le Zhang
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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windows xp
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2016-04-15T04:37:13
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2016-04-15T04:37:13
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