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Mycoplasmal cerebral vasculopathy in a lymphoma patient: presumptive evidence of Mycoplasma pneumoniae microvascular endothelial cell invasion in a brain biopsy

Descriptive

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TitleInfo
Title
Mycoplasmal cerebral vasculopathy in a lymphoma patient: presumptive evidence of Mycoplasma pneumoniae microvascular endothelial cell invasion in a brain biopsy
Name (type = personal)
NamePart (type = family)
Rhodes
NamePart (type = given)
Roy H.
Affiliation
Pathology and Laboratory Medicine (Robert Wood Johnson Medical School, RWJMS)-University Diagnostic Laboratories (UDL), Rutgers University
Role
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author
Name (type = personal)
NamePart (type = family)
Monastersky
NamePart (type = given)
Bruce T.
Role
RoleTerm (type = text); (authority = marcrt)
author
Affiliation
Neurological Associates of Ocean County
Name (type = personal)
NamePart (type = family)
Tyagi
NamePart (type = given)
Rachana
Affiliation
Surgery (Robert Wood Johnson Medical School, RWJMS), Rutgers University
Role
RoleTerm (type = text); (authority = marcrt)
author
Name (type = personal)
NamePart (type = family)
Coyne
NamePart (type = given)
Thomas
Affiliation
Pathology and Laboratory Medicine (Robert Wood Johnson Medical School, RWJMS)-University Diagnostic Laboratories (UDL), Rutgers University
Role
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author
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NamePart
Pathology and Laboratory Medicine (Robert Wood Johnson Medical School, RWJMS)-University Diagnostic Laboratories (UDL)
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NamePart
Robert Wood Johnson Medical School (RWJMS)
Name (type = corporate); (authority = RutgersOrg-Department)
NamePart
Surgery (Robert Wood Johnson Medical School, RWJMS)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
OriginInfo
DateIssued (encoding = w3cdtf); (keyDate = yes)
2011
Abstract (type = Abstract)
A 73-year-old man had episodic encephalopathy, ataxia and neuropathy. Symptoms largely resolved but adenopathy later lead to the diagnosis of a low-grade follicular lymphoma. The neurological symptoms soon recurred with new pontine calcifications identified by computed tomography. Brain biopsy revealed microvascular endothelial cell nuclear changes. Electron microscopy identified small polymorphic bacteria without a cell wall and with terminal and attachment organelles within endothelial cells and clustered in some microvascular lumina. Immunostaining was positive for Mycoplasma pneumoniae and convalescent serum enzyme immunoassay was positive for M. pneumoniae IgG. The patient again recovered and he was neurologically stable 33 months after the initial episode. The ultrastructural findings of the bacterial cells are distinctive of some mycoplasmal species when compared to other small bacteria. Mycoplasma-like organisms are reported in four autopsied patients who had chronic encephalopathy, movement disorders, and some of the same light- and electron-microscopic findings in the brain as our patient. Direct neuroinvasion by Mycoplasma species has been suggested, while anatomic observations in our patient and in the four autopsy cases show microvascular invasion but not parenchymal invasion. Most mycoplasmal encephalitis may be immune-mediated. The frequency of neurovascular invasion is not known. It may be rare and it may persist.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
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application/pdf
Extent
19 p.
Subject (authority = local)
Topic
Mycoplasma species
Subject (authority = local)
Topic
Vasculopathy
Subject (authority = local)
Topic
Encephalopathy
Subject (authority = local)
Topic
Gait disorder
Subject (authority = local)
Topic
Immunodeficiency
Subject (authority = local)
Topic
Cerebral biopsy
Subject (authority = local)
Topic
Immunostaining
Subject (authority = local)
Topic
Electron microscopy
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2011
AssociatedObject
Name
Journal of the Neurological Sciences
Type
Journal
Relationship
Has part
Detail
18-25
Identifier (type = volume and issue)
309(1-2)
Reference (type = url)
http://dx.doi.org/10.1016/j.jns.2011.07.043
Note (type = peerReview)
Peer reviewed.
RelatedItem (type = host)
TitleInfo
Title
Tyagi, Rachana
Identifier (type = local)
rucore30213300001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3862JP0
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Rights

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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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