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The influence of dietary fat and intestinal pH on calcium bioaccessibility

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TitleInfo
Title
The influence of dietary fat and intestinal pH on calcium bioaccessibility
SubTitle
an in vitro study
Name (type = personal)
NamePart (type = family)
Bandali
NamePart (type = given)
Elhaam
NamePart (type = date)
1990-
DisplayForm
Elhaam Bandali
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shapses
NamePart (type = given)
Sue
DisplayForm
Sue Shapses
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Human studies measuring true fractional calcium absorption have shown that dietary fat is a significant predictor of calcium absorption. In murine models, dietary fat also increases calcium absorption, but whether there is a differential effect with the type of fatty acid (FA) on intestinal calcium absorption is less clear. Compared to monounsaturated FAs (MUFAs), saturated FAs (SFAs) decrease lipid membrane fluidity and have a greater intestinal transit time, potentially prolonging their interaction with calcium in the gut. In addition, SFAs bind to calcium forming insoluble soaps, increasing fecal fat excretion, and reducing calcium availability for absorption. In addition, luminal factors such as a higher pH in the GI tract could influence calcium absorption such as with certain medications or achlorhydria. The TNO gastrointestinal model (TIM-1) replicates the physiological activities occurring in the lumen of the stomach, duodenum, jejunum, and ileum and is used to study biological events preceding nutrient absorption (i.e., bioaccessibility). In this study, we examined two high fat formulas (SFA or MUFA enriched) compared to low fat and controlled for calcium (500 mg) and other micronutrients during a 5-hr experiment. Calcium bioaccessibility (CaB) was greater for the high compared to low fat test meal in the jejunum (p = 0.001). In addition, CaB with the SFA alone was higher than either LFD or MUFA (p < 0.01). However, there was no interaction between diet and CaB in the ileum or ileal efflux. During high gastrointestinal pH, CaB was similar between diets in the jejunum and ileum, and there was a trend for increasing non-bioaccessible calcium over time (p = 0.058). Furthermore, CaB was 90% (p = 0.003), 91% (p = 0.036), and 94% (p = 0.001) lower in the jejunum, ileum, and ileal efflux, respectively at high pH compared to normal gastrointestinal conditions. These findings suggest a dramatically lower CaB under high pH conditions, having implications for a wide range of patients with gastrointestinal disorders. In addition, the higher Ca absorption associated with a high fat diet found previously, may be partially explained by an increased CaB.
Subject (authority = RUETD)
Topic
Nutritional Sciences
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7711
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 54 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Calcium--Metabolism
Note (type = statement of responsibility)
by Elhaam Bandali
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T31Z46QG
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Bandali
GivenName
Elhaam
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-10-02 19:17:07
AssociatedEntity
Name
Elhaam Bandali
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2018-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2018.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2016-10-02T19:12:40
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2016-10-02T19:12:40
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