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Compartment based population balance model development and validation of a high shear wet granulation process via dry binder addition
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Bandi, Chandra Kanth. Compartment based population balance model development and validation of a high shear wet granulation process via dry binder addition. Retrieved from https://doi.org/doi:10.7282/T3X63Q8Z

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TitleCompartment based population balance model development and validation of a high shear wet granulation process via dry binder addition
NameBandi, Chandra Kanth (author); Ramachandran, Rohit (chair); Singh, Ravendra (internal member); Callegari, Gerardo (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-10 (degree)
SubjectChemical and Biochemical Engineering, Drugs--Granulation
Extent1 online resource (vii, 38 p. : ill.)
DescriptionThe addition of binder to facilitate the granulation in high shear wet granulation (HSWG) process can be achieved either by adding a binder liquid with uniform viscosity and binder content (wet binder addition) or by adding a liquid to the pre-mixed mixture of solid binder and aggregating granules, that dissolves the binder enabling varying viscosity (dry binder addition). Population balance modeling has been used traditionally to model the wet binder addition (WBA) systems. However, these models solely cannot represent the dry binder addition (DBA) systems which includes an additional process of dissolution of binder in liquid. In this work, a reduced ordered compartment based population balance model (PBM) integrated with particle dissolution model was developed to address the di erences in particle size distribution obtained from dry and wet binder addition granulation. The experimental data for the HSWG process using WAB and DBA was obtained from Bristol-Myers-Squibb. The data was used to estimate the kernel parameters to validate the integrated model to be used as predictive tool. This model showed good agreements with experimental data in capturing the trends in mean particle size.
NoteM.S.T.
NoteIncludes bibliographical references
Noteby Chandra Kanth Bandi
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3X63Q8Z
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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