The addition of binder to facilitate the granulation in high shear wet granulation (HSWG) process can be achieved either by adding a binder liquid with uniform viscosity and binder content (wet binder addition) or by adding a liquid to the pre-mixed mixture of solid binder and aggregating granules, that dissolves the binder enabling varying viscosity (dry binder addition). Population balance modeling has been used traditionally to model the wet binder addition (WBA) systems. However, these models solely cannot represent the dry binder addition (DBA) systems which includes an additional process of dissolution of binder in liquid. In this work, a reduced ordered compartment based population balance model (PBM) integrated with particle dissolution model was developed to address the di erences in particle size distribution obtained from dry and wet binder addition granulation. The experimental data for the HSWG process using WAB and DBA was obtained from Bristol-Myers-Squibb. The data was used to estimate the kernel parameters to validate the integrated model to be used as predictive tool. This model showed good agreements with experimental data in capturing the trends in mean particle size.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7732
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 38 p. : ill.)
Note (type = degree)
M.S.T.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Drugs--Granulation
Note (type = statement of responsibility)
by Chandra Kanth Bandi
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
Rutgers University. Graduate School - New Brunswick
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Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.