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Optimization and troubleshooting of polymer synthesis for self-assembly of tyrosine-based nanospheres
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Davie, Dania Karina Agüero. Optimization and troubleshooting of polymer synthesis for self-assembly of tyrosine-based nanospheres. Retrieved from https://doi.org/doi:10.7282/T3JQ13BD

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TitleOptimization and troubleshooting of polymer synthesis for self-assembly of tyrosine-based nanospheres
NameDavie, Dania Karina Agüero (author); Kohn, Joachim (chair); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-10 (degree)
SubjectChemistry and Chemical Biology, Polymers
Extent1 online resource (xvii, 62 p. : ill.)
DescriptionSynthesis of poly(ethylene glycol)-block-oligo(DTO suberate) -block-poly(ethylene glycol), a tyrosine-based ABA triblock copolymer was conducted in an effort to match specifications of a previous batch of polymer used in to self-assemble into nanospheres for drug delivery in previously published work. Though synthesis was successful and the polymer’s physical and thermal specifications were met, the resulting nanospheres did not meet the size specifications of past samples. Polymer synthesis was optimized both by varying the amount of coupling agent used in the reaction as well as varying the monomeric excess of suberic acid using the Carothers's equation. This work resulted in tunable nanospheres based on polymer molecular weight. Varying of coupling agent was found to produce polymers of different molecular weights albeit in a random fashion. Use of monomeric excess was found to reproducibly produce polymers of varying molecular weights. Additionally nanosphere preparation was also studied to determine whether the use of sucrose during nanosphere self-assembly would result in an increased polymer yield. The use of a sucrose solution during nanosphere preparation was found to cause no improvement in polymer yield and is in fact believed to have the opposite effect.
NoteM.S.
NoteIncludes bibliographical references
Noteby Dania Karina Agüero Davie
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3JQ13BD
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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