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Optimization and troubleshooting of polymer synthesis for self-assembly of tyrosine-based nanospheres

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TitleInfo
Title
Optimization and troubleshooting of polymer synthesis for self-assembly of tyrosine-based nanospheres
Name (type = personal)
NamePart (type = family)
Davie
NamePart (type = given)
Dania Karina Agüero
NamePart (type = date)
1984-
DisplayForm
Dania Karina Agüero Davie
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Kohn
NamePart (type = given)
Joachim
DisplayForm
Joachim Kohn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Synthesis of poly(ethylene glycol)-block-oligo(DTO suberate) -block-poly(ethylene glycol), a tyrosine-based ABA triblock copolymer was conducted in an effort to match specifications of a previous batch of polymer used in to self-assemble into nanospheres for drug delivery in previously published work. Though synthesis was successful and the polymer’s physical and thermal specifications were met, the resulting nanospheres did not meet the size specifications of past samples. Polymer synthesis was optimized both by varying the amount of coupling agent used in the reaction as well as varying the monomeric excess of suberic acid using the Carothers's equation. This work resulted in tunable nanospheres based on polymer molecular weight. Varying of coupling agent was found to produce polymers of different molecular weights albeit in a random fashion. Use of monomeric excess was found to reproducibly produce polymers of varying molecular weights. Additionally nanosphere preparation was also studied to determine whether the use of sucrose during nanosphere self-assembly would result in an increased polymer yield. The use of a sucrose solution during nanosphere preparation was found to cause no improvement in polymer yield and is in fact believed to have the opposite effect.
Subject (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (authority = ETD-LCSH)
Topic
Polymers
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7588
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xvii, 62 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Dania Karina Agüero Davie
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3JQ13BD
Genre (authority = ExL-Esploro)
ETD graduate
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RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Davie
GivenName
Dania
MiddleName
Karina Agüero
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-09-19 10:34:17
AssociatedEntity
Name
Dania Davie
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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windows xp
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2016-10-06T20:29:35
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2016-10-06T20:29:35
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