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Comparison of non-toxic methods for creating beta-carotene encapsulated in pmma nanoparticles

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TitleInfo
Title
Comparison of non-toxic methods for creating beta-carotene encapsulated in pmma nanoparticles
Name (type = personal)
NamePart (type = family)
Dobrzanski
NamePart (type = given)
Christopher D.
NamePart (type = date)
1987-
DisplayForm
Christopher D. Dobrzanski
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina C
DisplayForm
Nina C Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Dutt
NamePart (type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Tomassone
NamePart (type = given)
Silvina
DisplayForm
Silvina Tomassone
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Nano/microcapsules are becoming more prevalent in various industries such as drug delivery, cosmetics, etc. Current methods of particle formation often use toxic or carcinogenic/mutagenic/reprotoxic (CMR) chemicals. This study intends to improve upon existing methods of particle formation and compare their effectiveness in terms of entrapment efficiency, mean particle size, and yield utilizing only non-toxic chemicals. In this study, the solvent evaporation (SE), spontaneous emulsification, and spontaneous emulsion solvent diffusion (SESD) methods were compared in systems containing green solvents ethyl acetate, dimethyl carbonate or acetone. PMMA particles containing encapsulated beta carotene, an ultraviolet sensitive substance, were synthesized. It was desired to produce particles with minimum mean size and maximum yield and entrapment of beta carotene. The mass of the water phase, the mass of the polymer and the pumping or blending rate were varied for each synthesis method. The smallest particle sizes for SE and SESD both were obtained from the middle water phase sizes, 200 g and 100 g respectively. The particles obtained from the larger water phase in SESD were much bigger, about 5 microns in diameter, even larger than the ones obtained from SE. When varying the mass of PMMA used in each synthesis method, as expected, more PMMA led to larger particles. Increasing the blending rate in SE from 6,500 to 13,500 rpm had a minimal effect on average particle size, but the higher shear resulted in highly polydisperse particles (PDI = 0.87). By decreasing the pump rate in SESD, particles became smaller and had lower entrapment efficiency. The entrapment efficiencies of the particles were generally higher for the larger particles within a mode. Therefore, we found that minimizing the particle size while maximizing entrapment were somewhat contradictory goals. The solvent evaporation method was very consistent in terms of the values of mean particle size, yield, and entrapment efficiency. Comparing the synthesis methods, the smallest particles with the highest yield and entrapment efficiency were generated by the spontaneous emulsification method.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7679
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 42 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Christopher D. Dobrzanski
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T34J0HFW
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Dobrzanski
GivenName
Christopher
MiddleName
D.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-09-29 08:20:35
AssociatedEntity
Name
Christopher Dobrzanski
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-10-06T11:27:38
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2016-10-06T11:27:38
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