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Design and characterization of three dimensional twist-braid scaffolds for anterior cruciate ligament replacement
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Madhavarapu, Shreya. Design and characterization of three dimensional twist-braid scaffolds for anterior cruciate ligament replacement. Retrieved from https://doi.org/doi:10.7282/T30C4Z3B

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TitleDesign and characterization of three dimensional twist-braid scaffolds for anterior cruciate ligament replacement
NameMadhavarapu, Shreya (author); Freeman, Joseph W (chair); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-10 (degree)
SubjectBiomedical Engineering, Ligaments, Anterior cruciate ligament
Extent1 online resource (x, 45 p. : ill.)
DescriptionThe anterior cruciate ligament (ACL) is the most commonly injured ligament in the knee, with more than 350,000 ACL injuries reported annually in the United States. Current treatments include the use of autografts and allografts which have a number of disadvantages. Previous attempts to use synthetic materials in ligament replacement have been unsuccessful due to their inability to replicate the long-term mechanical properties of the native ligament. This project focuses on developing twist-braid poly(L-lactic acid) (PLLA) scaffolds for ACL replacement. Poly(ethylene glycol) diacrylate (PEGDA) was incorporated into the twist-braid scaffolds to evaluate its impact on their mechanical behavior. The twist-braid scaffolds were also compared with braided scaffolds. Scaffold mechanical properties were evaluated based on stress-relaxation, tensile and fatigue properties of the braided-only, twist-braid and the twist-braid scaffolds with PEGDA. All the scaffolds exhibited properties comparable to the native human ACL with the twist-braid scaffolds displaying resistance to fatigue. Scaffolds were seeded with rat patellar tendon fibroblasts. The cell viability and amount of protein released was studied over a course of 8 weeks. The scaffolds were stained with picrosirius red after 8 weeks to show the deposition of extracellular matrix by the cells. The results from this study showed that the twist-braid scaffolds have properties most suitable for ligament replacement.
NoteM.S.
NoteIncludes bibliographical references
Noteby Shreya Madhavarapu
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T30C4Z3B
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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