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Hepatic transcriptional dynamics following burn and sepsis

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TitleInfo
Title
Hepatic transcriptional dynamics following burn and sepsis
SubTitle
the profile of the systemic inflammatory response
Name (type = personal)
NamePart (type = family)
Mattick
NamePart (type = given)
John Stocker Antalis
DisplayForm
John Stocker Antalis Mattick
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Androulakis
NamePart (type = given)
Ioannis P
DisplayForm
Ioannis P Androulakis
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Roth
NamePart (type = given)
Charles M
DisplayForm
Charles M Roth
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Ierapetritou
NamePart (type = given)
Marianthi
DisplayForm
Marianthi Ierapetritou
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
This thesis aims to understand the dynamic impact of injury on liver metabolism and protein production. Hypermetabolism is a major clinical complication arising from systemic inflammation in the liver. Thus, this thesis hypothesizes that major inflammation driving stressors will be able to induce both metabolic and pro-inflammatory changes to liver gene expression. Animals were induced into an inflammatory state either by Burn, Cecal Ligation and Puncture (CLP), or Sham Cecal Ligation and Puncture (SCLP). CLP and SCLP, characterized previously by their cytokine outputs, were functionally annotated and subjected to pathway analysis following RNA expression measurement. Acute phase differences between CLP and SCLP show a much more severe acute CLP response, including a significant number of anti-bacterial proteins. Long term responses to CLP compared to SCLP show a significant anti-inflammatory surge, along with signs of oxidative stress sensitivity. When primed with burn injury, the CLP acute inflammatory response becomes depressed, but surges back stronger at later time points, suggesting early immune vulnerability followed by deleterious overcompensation. Overall, these studies reveal an underlying complexity to the sepsis models that suggest multiple avenues towards deleterious inflammation that may be clinically addressed.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = ETD-LCSH)
Topic
Septicemia
Subject (authority = ETD-LCSH)
Topic
Burns and scalds
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7731
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (ix, 86 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by John Stocker Antalis Mattick
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3348NQQ
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Mattick
GivenName
John
MiddleName
Stocker Antalis
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-10-03 11:27:03
AssociatedEntity
Name
John Mattick
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2017-01-12T13:15:15
CreatingApplication
Version
1.7
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