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Design of peptide inhibitors for influenza a non-structural protein 1
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Nosker, Patrick Leonard. Design of peptide inhibitors for influenza a non-structural protein 1. Retrieved from https://doi.org/doi:10.7282/T38P62VS

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TitleDesign of peptide inhibitors for influenza a non-structural protein 1
NameNosker, Patrick Leonard (author); Stock, Ann M (chair); Case, David A (internal member); Nanda, Vikas (internal member); Roth, Monica J (outside member); Montelione, Gaetano T (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-10 (degree)
SubjectComputational Biology and Molecular Biophysics, Influenza A virus, Peptides
Extent1 online resource (xiv, 156 p. : ill.)
DescriptionInfluenza A is responsible for tens of thousands of annual fatalities in the United States. The conventional medical strategy relies on prevention of infection using vaccines where are mildly effective at best and require yearly updates to reflect the expected prevalent strains, and anti-viral drugs for which there is significant clinical resistance. With this in mind, the non-structural protein 1 of influenza A (NS1A) is an appropriate target with high conservation and a multitude of anti-immune effects. It features an array of high surface area interactions which may be targetable using peptides. We are developing molecular design tools to reliably create short (<20 amino acid) molecules with half-life and stability sufficient for drug-like function. In this thesis, I will explore D-amino acid motifs for increasing stability of peptides in the ideal Trp-cage peptide system and implement designed motifs in peptides designed to target the NS1A protein. Finally, we will demonstrate inhibition of the NS1A protein using our designed peptides.
NotePh.D.
NoteIncludes bibliographical references
Noteby Patrick Leonard Nosker
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T38P62VS
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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