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Exercise as a neurobehavioral therapy for cognitive control deficits in major depressive disorder

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TitleInfo
Title
Exercise as a neurobehavioral therapy for cognitive control deficits in major depressive disorder
Name (type = personal)
NamePart (type = family)
Olson
NamePart (type = given)
Ryan L.
DisplayForm
Ryan L. Olson
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Alderman
NamePart (type = given)
Brandon L
DisplayForm
Brandon L Alderman
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Bello
NamePart (type = given)
Nicholas T
DisplayForm
Nicholas T Bello
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Shapses
NamePart (type = given)
Sue A
DisplayForm
Sue A Shapses
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Campbell
NamePart (type = given)
Sara C
DisplayForm
Sara C Campbell
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Shors
NamePart (type = given)
Tracey J
DisplayForm
Tracey J Shors
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2016
Place
PlaceTerm (type = code)
xx
Language
LanguageTerm (authority = ISO639-2b); (type = code)
eng
Abstract (type = abstract)
Major depressive disorder (MDD) is associated with a number of symptoms, including cognitive dysfunction and maladaptive ruminative thought patterns. Although consistent evidence indicates that aerobic exercise is beneficial for reducing depressive symptoms in MDD, little is known about the influence of exercise on neurocognitive deficits found in depression. This is important for establishing exercise as a neurobehavioral therapy for depression, that is, an intervention that addresses biological mechanisms believed to underlie the disorder. Here, we investigated whether the N2 and P3 components of the human event-related potential (ERP) could be used to index cognitive impairments in MDD, and whether these neurophysiological measures were correlated with ruminative thought patterns. Although there were no differences in P3 amplitude by depression status, N2 amplitudes were significantly reduced in individuals with MDD relative to healthy controls, indicating that reductions were associated with higher rumination levels. These findings demonstrate that individuals with MDD may experience impaired cognitive control while attending to varying environmental stimuli. Because of our findings related to impaired cognitive control processes, we examined the neurophysiological and behavioral correlates of cognitive control during single bouts of low- and moderate-intensity exercise in healthy young adults to determine if neurocognitive function is modifiable by aerobic exercise. Importantly, acute exercise was shown to modify these ERP components, such that increased N2 and P3 amplitudes were found during exercise at low and moderate intensities relative to rest. Although this study was performed in nondepressed participants, it suggests an upregulation of cognitive control during aerobic exercise that may be maintained through a program of chronic exercise. Finally, we examined the effects of a moderate-intensity aerobic exercise intervention performed three days/week for 8 weeks. The aerobic exercise condition exhibited enhanced cognitive control (i.e., N2 amplitude) and reduced depressive symptoms among individuals with MDD; however, these exercise-induced changes in cognitive control were not found to significantly mediate pre-to-post changes in symptom outcomes. These findings support the use of exercise as a neurobehavioral therapy for MDD and suggest the possibility of incorporating exercise as a stand alone or augmentation strategy for conventional treatments.
Subject (authority = RUETD)
Topic
Nutritional Sciences
Subject (authority = ETD-LCSH)
Topic
Depressive disorder--Treatment
Subject (authority = ETD-LCSH)
Topic
Depression, Mental--Treatment
Subject (authority = ETD-LCSH)
Topic
Exercise
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_7734
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xvi, 131 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Ryan L. Olson
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3MW2KGQ
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Olson
GivenName
Ryan
MiddleName
L.
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-10-03 13:31:51
AssociatedEntity
Name
Ryan Olson
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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windows xp
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DateCreated (point = start); (encoding = w3cdtf); (qualifier = exact)
2016-10-04T14:46:01
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2016:10:04 19:44Z
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Adobe Mac PDF Plug-in
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