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Strategies to overcome physicochemical and biological barriers in chemotherapy by formulation and drug delivery device combination
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Shah, Milinkumar. Strategies to overcome physicochemical and biological barriers in chemotherapy by formulation and drug delivery device combination. Retrieved from https://doi.org/doi:10.7282/T3FX7CTD

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TitleStrategies to overcome physicochemical and biological barriers in chemotherapy by formulation and drug delivery device combination
NameShah, Milinkumar (author); Minko, Tamara (chair); You, Guofeng (internal member); Michniak-Kohn, Bozena (internal member); Gaudana, Ripal (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-10 (degree)
SubjectPharmaceutical Science, Cyclodextrins, Chemotherapy
Extent1 online resource (xiv, 134 p. : ill.)
DescriptionThe success of chemotherapy depends on efficacy of drug to enter the cancer cell to exert cytotoxicity. This feat is extremely challenging for drugs with low solubility and permeability which leads to inadequate concentrations in cancer cells resulting in therapeutic failure. For potent drugs like Paclitaxel (PTX), this drawback can be overcome by reformulation approach. The objective of the research is to improve PTX aqueous solubility and permeability by using suitable approach such as formulating inclusion complexes of PTX with various β-cyclodextrin (CD) derivatives. It was hypothesized that complexation will improve aqueous solubility of PTX and expand cellular internalization. This concept was verified by testing prepared complexes and understanding their physicochemical interactions. Later, the complexes were further evaluated with respect to excipient safety and efficacy of reformulated PTX under in vitro conditions. Achieving desired therapeutic levels within the brain for the treatment of neurological conditions and brain cancers is a formidable task due to blood brain barrier's (BBB) ability to restrict different drugs. A non-invasive approach of nose to brain delivery to bypass BBB is proven but has many limitations such as small dose volume and precise delivery. Drug distribution to brain can be improved by using a device that can precisely deliver the formulation in the olfactory region of nasal cavity and provide rapid and direct access to brain. The objective was to evaluate the feasibility of using intranasal liposomal formulation to carry cargo of variety of drugs and oligonucleotides to brain. The hypothesis was verified by applying liposomal formulation in combination with a drug delivery device and comparing brain accumulation with intravenous route of administration.
NotePh.D.
NoteIncludes bibliographical references
Noteby Milinkumar Shah
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3FX7CTD
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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