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Strategies to overcome physicochemical and biological barriers in chemotherapy by formulation and drug delivery device combination
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Descriptive

TitleInfo
Title
Strategies to overcome physicochemical and biological barriers in chemotherapy by formulation and drug delivery device combination
Name (type = personal)
NamePart (type = family)
Shah
NamePart (type = given)
Milinkumar
NamePart (type = date)
1981-
DisplayForm
Milinkumar Shah
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Minko
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Tamara
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Tamara Minko
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Advisory Committee
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chair
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You
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Guofeng
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Guofeng You
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Advisory Committee
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internal member
Name (type = personal)
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Michniak-Kohn
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Bozena
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Bozena Michniak-Kohn
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Advisory Committee
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internal member
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Ripal
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Ripal Gaudana
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Advisory Committee
Role
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outside member
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Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated (qualifier = exact)
2016
DateOther (qualifier = exact); (type = degree)
2016-10
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2016
Place
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xx
Language
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eng
Abstract (type = abstract)
The success of chemotherapy depends on efficacy of drug to enter the cancer cell to exert cytotoxicity. This feat is extremely challenging for drugs with low solubility and permeability which leads to inadequate concentrations in cancer cells resulting in therapeutic failure. For potent drugs like Paclitaxel (PTX), this drawback can be overcome by reformulation approach. The objective of the research is to improve PTX aqueous solubility and permeability by using suitable approach such as formulating inclusion complexes of PTX with various β-cyclodextrin (CD) derivatives. It was hypothesized that complexation will improve aqueous solubility of PTX and expand cellular internalization. This concept was verified by testing prepared complexes and understanding their physicochemical interactions. Later, the complexes were further evaluated with respect to excipient safety and efficacy of reformulated PTX under in vitro conditions. Achieving desired therapeutic levels within the brain for the treatment of neurological conditions and brain cancers is a formidable task due to blood brain barrier's (BBB) ability to restrict different drugs. A non-invasive approach of nose to brain delivery to bypass BBB is proven but has many limitations such as small dose volume and precise delivery. Drug distribution to brain can be improved by using a device that can precisely deliver the formulation in the olfactory region of nasal cavity and provide rapid and direct access to brain. The objective was to evaluate the feasibility of using intranasal liposomal formulation to carry cargo of variety of drugs and oligonucleotides to brain. The hypothesis was verified by applying liposomal formulation in combination with a drug delivery device and comparing brain accumulation with intravenous route of administration.
Subject (authority = RUETD)
Topic
Pharmaceutical Science
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_7554
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiv, 134 p. : ill.)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Subject (authority = ETD-LCSH)
Topic
Cyclodextrins
Subject (authority = ETD-LCSH)
Topic
Chemotherapy
Note (type = statement of responsibility)
by Milinkumar Shah
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3FX7CTD
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Shah
GivenName
Milinkumar
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2016-09-11 12:27:09
AssociatedEntity
Name
Milinkumar Shah
Role
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Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
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Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2016-09-11T10:42:19
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2016-09-11T10:42:41
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Adobe PDF Library 11.0
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